泰兴市原发性肝癌病例对照家系研究  

A CASE-CONTROL FAMILY STUDY OF HEPATOCELLULAR CARCINOMA IN TAIXING AREA

作　　者：岑玉玲[1] 郜艳晖[2] 丁保国[3] 周学富[3] 张敏[2] 叶小华[2] 姜庆五[4] 

机构地区：[1]广东药学院公共卫生学院,预防医学专业02级广州510310 [2]广东药学院公共卫生学院流行病与卫生统计学系 [3]江苏省泰兴市疾病预防控制中心 [4]复旦大学公共卫生学院流行病学教研室

出　　处：《现代预防医学》2008年第20期3903-3904,3910,共3页Modern Preventive Medicine

基　　金：国家自然科学基金(30500421)

摘　　要：[目的]评价遗传因素及环境因素在原发性肝癌发生中的作用。[方法]采用以人群为基础的1:1病例对照家系设计,应用条件logistic回归模型对泰兴市202例原发性肝癌病例家系和202例对照家系数据进行拟合,以AIC值最小作为判断拟合优度的标准。[结果]HBsAg阳性为原发性肝癌发病的危险因素,而饮自来水是保护因素。父母表型与子女肝癌发病相关。[结论]原发性肝癌是环境因素与遗传因素共同作用的结果。[Objective] To estimate the various genetic and environmental components contributing to hepatocellular carcinoma （HCC）. [ Methods ] A population-based 1 ： 1 pair-matched case-control family study was conducted. Conditional logistic regressive model was used to fit genealogy of 202 patients with primary hepatic carcinoma and 202 controls, and the minimum AIC was used to be the standard to determine the goodness of fit. [ Results] HBsAg carrier status was the risk factor for HCC, and drinking tap water was protective factor. The phenotype of parents was associated with an increased risk of HCC of the children. [Conclusion] HCC is multifactorial disease with various genetic and environmental factors involved in its etiology.

关 键 词：原发性肝癌 病例对照家系研究 条件logistic模型 

分 类 号：R735.7[医药卫生—肿瘤]