二氢杨梅素的降血糖及保护肾脏损伤效果研究  

Influence of Dihydromyricetin on the Blood Glucose Concentration and Early Kidney's Damage in Impaired Glucose Tolerance Rats

作　　者：郑成[1] 陈静[2] 郭丽娜[3] 哈成勇[4] 

机构地区：[1]广州大学化学化工学院,广东广州510006 [2]暨南大学医学院营养教研室,广东广州510632 [3]广东省中医院营养科,广东广州510120 [4]中国科学院广州化学研究所,广东广州510650

出　　处：《精细化工》2008年第10期966-969,共4页Fine Chemicals

基　　金：广东省科技厅资助项目(批准号[2005]143)~~

摘　　要：以D-半乳糖为诱导剂,采用剂量递增全程腹腔注射法建立糖耐量异常动物模型。以二氢杨梅素为受试物,实验8周后,测定各实验组大鼠空腹及餐后2h血糖、胰岛素水平、尿微量白蛋白、尿素氮以及肾脏乳酸脱氢酶比活。与模型组相比,二氢杨梅素能显著降低餐后2h血糖及胰岛素水平(P<0.05),尿微量白蛋白含量及乳酸脱氢酶比活均明显降低(P<0.05),而尿素氮水平变化不明显(P>0.05)。尿微量白蛋白及乳酸脱氢酶可作为检测肾脏早期损伤的敏感指标。结果表明:二氢杨梅素可明显改善大鼠糖耐量异常状态,对肾脏早期损伤具有一定保护作用。In this paper, the influence of dihydromyricetin on lowering blood glucose concentration and reducing early kidney damage in IGT rats was studied. Animal model of IGT rats was built by two week intragastric injection of D-galactose and treated with eight weeks of intragastrie injection of dihydromyrieetin at two dose levels. The concentrations of fasting blood glucose, two-hour postprandial blood glucose, insulin levels, contents of microalbuminuia and blood urea nitrogen, and activities of lactate dehydrogenase （LDH） in kidney were analysed and compared with those in control groups. Experimental results indicated that dihydromyricetin treatment can significantly lower the levels of two- hour postprandial blood glucose and insulin, decrease the content of microalbuminuia and the activities of LDH in kidney, but does not influence the level of blood urea nitrogen. The study suggested that dihydromyricetin can effectively improve the states of IGT rats and provide a protective effect against early kidney damage.

关 键 词：二氢杨梅素 肾脏早期损伤 尿微量白蛋白 乳酸脱氢酶 尿素氮 中药现代化技术 

分 类 号：R151.41[医药卫生—营养与食品卫生学] TQ420.66[医药卫生—公共卫生与预防医学]