盐酸马布特罗的合成  

Synthesis of mabuterol hydrochloride

作　　者：潘莉[1] 杜桂杰[1] 葛丹丹[1] 邢瑞娟[1] 程卯生[1] 

机构地区：[1]沈阳药科大学制药工程学院,辽宁沈阳110016

出　　处：《中国药物化学杂志》2008年第5期353-354,共2页Chinese Journal of Medicinal Chemistry

基　　金：国家高科技研究发展计划重大专项(2005AA2Z3D50)

摘　　要：目的研究β2-受体兴奋剂盐酸马布特罗的合成工艺。方法以3-氯-4-氨基-5-三氟甲基苯乙酮为起始原料,经溴代、胺解、还原和成盐反应制得盐酸马布特罗。结果与结论目标化合物的结构经红外光谱1、H-NMR1、3C-NMR和质谱确证,总收率为8.5%。该合成工艺操作简便,适合工业化生产。Aim To study the synthetic procedure of mabuterol hydrochloride. Methods The target compound was synthesized from 4-amino-3-chloro-5-trifluoromethylphenylnone via hromination, amination, reduction and salt formation. Results and conclusion The structure of mahuterol hydrochloride was confirmed by IR, ^1H-NMR, ^13C-NMR and MS, and the overall yield was 8.5 %. This synthetic process is easy to scale up for its convenient operation.

关 键 词：工艺研究 盐酸马布特罗 β2-受体兴奋剂 

分 类 号：R914[医药卫生—药物化学]