伊立替康联合顺铂时辰化疗治疗小细胞肺癌的临床研究  

Chrono-chemotherapy with irinotecan plus cisplatin for small cell lung cancer

作　　者：别俊[1] 李光明[1] 文世明[1] 任大成[1] 

机构地区：[1]川北医学院第二临床医学院南充市中心医院肿瘤防治中心,四川南充637000

出　　处：《西部医学》2008年第6期1150-1152,共3页Medical Journal of West China

基　　金：四川省卫生厅科研项目(No.050246)

摘　　要：目的比较伊立替康联合顺铂的时辰化疗与常规化疗治疗小细胞肺癌(SCLC)的疗效和不良反应。方法60例非小细胞肺癌患者随机分为两组,时辰组31例予时辰化疗,伊立替康60mg/m2静脉滴注第1、8、15天,于上午02:00开始,至08:00结束,顺铂60mg/m2静脉滴注,第1天,上午10:00开始,至下午22:00结束;对照组29例予常规化疗,每天上午10:00给予伊立替康联合顺铂(两药剂量同时辰化疗组),化疗至少两周期后评价近期疗效。结果时辰化疗组有效率(CR+PR)为87.1%(27/31),常规化疗组有效率为(CR+PR)为65.5%(19/29),两组有效率比较,差异有统计学意义(P<0.05);主要不良反应为血液学毒性、恶心呕吐及延迟性腹泻,时辰化疗组较常规化疗组低(P<0.05)。结论伊立替康联合顺铂时辰化疗治疗小细胞肺癌疗效高于常规化疗,毒副反应轻,值得进一步深入研究。Objective To compare the efficacy and toxicity of chrono-chemotherapy （irinotecan and cisplatin） with routine - chemotherapy for small cell lung cancer. Methods 60 cases of SCLC patients were randomly grouped ,31 cases for chrono-chemotherapy were treated with irinotecan 60mg/m^2, from 2 ： 00AM to 8： AM, cisplatin 60mg/m^2, from 10： 00AM to 22：00PM; and 29 cases were treated with conventional chemotherapy preoceeded on 10AM, For needs of evaluation, all patients must complete at least two cycles. Results The totle response rate （CR＋PR） in chrono-chemotherapy and conventional chemotherapy were 87.1% and 65.5% respectively, The difference between two groups had statistical significance, The main adverse events of chemotherapy were leucopenia, gastro intestinal discomfort and delayed diarrhea, the toxicity of chrono-chemotherapy groups were lowed to routine - chemotherapy groups, The difference between two groups had statistical significance. Conclusion The chrono-chemotherapy （irinotecan and cisplatin） was more effective than routine - chemotherapy for small cell lung cancer, and had lower adverse reactions as well. More clinical research should be taken.

关 键 词：小细胞肺癌 时辰化疗 伊立替康 顺铂 

分 类 号：R734.2[医药卫生—肿瘤]