两种含奥美拉唑的四联疗法抗幽门螺杆菌的疗效观察  

Quadruple therapy of omeprazole and ranitidine bismuth citrate for helicobacter pylori infection

作　　者：林青 

机构地区：[1]南充市顺庆区人民医院药剂科,四川南充637000

出　　处：《西部医学》2008年第6期1274-1275,共2页Medical Journal of West China

摘　　要：目的比较奥美拉唑与枸橼酸铋雷尼替丁四联疗法和奥美拉唑与三甲二枸橼酸铋四联疗法根除幽门螺杆菌(Hp)的疗效及安全性。方法选择Hp感染的活动期溃疡或糜烂性胃窦炎患者,随机分为A、B两组。分别用奥美拉唑与三甲二枸橼酸铋四联疗法和奥美拉唑与枸橼酸铋雷尼替丁四联疗法根除Hp治疗,活动期溃疡抗Hp治疗后继续服奥美拉唑20毫克,1次/d,疗程2周。观察Hp的根除率、活动期溃疡和糜烂性胃窦炎的愈合率以及副作用的发生率。结果奥美拉唑与枸橼酸铋雷尼替丁四联疗法组Hp根除率(95.35%),显著高于奥美拉唑与三甲二枸橼酸铋四联疗法(63.64%,P<0.05),奥美拉唑与枸橼酸铋雷尼替丁四联疗法组与奥美拉唑及三甲二枸橼酸铋四联疗法组对活动期溃疡愈合率差异无统计学意义(P>0.05);奥美拉唑与枸橼酸铋雷尼替丁四联疗法组对糜烂性胃窦炎的愈合率显著高于奥美拉唑与三甲二枸橼酸铋四联疗法(P<0.05)。不良反应发生率无统计学差异(P>0.05)。结论奥美拉唑与RBC联合四联疗法可获得较高Hp根除率,不良反应少,值得进一步试用。Ojective To evaluate the efficacy and security of the quadruple chemotherapy composed of omeprazole and ranitidine bismuth citrate（RBC） to treat helicobacter pylori infection. Methods Patients with peptic ulcer or chronic erosion gastritis and Hp infection were randomly allocated into 2 group, including Group A and Group B. Group A included omeprazole, colloidal bismuth subcitrate, amoxicillin and furaltadone. Group B included omeprazole, RBC, amoxicillin and furaltadone. Results The Hp eradication rate of Group A was 63.64% of, which was significantly lower than that of Group B（95.35%）（P〈0.05）. The ulcer healing rates of the groups were close to each other. The erosion gastritis healing rate of B Groups was higher than that of Group A（P〈0. 05）. The adverse effect rate of Group A and Group B were 17.78% and 13.33%, respectively, which were not significantly different from each other（P〉0.05）. Conclusion The quadruple chemotherapy of omeprazole and ranitidine bismuth citrate is safe and effective in eradicating Hp infection.

关 键 词：幽门螺杆菌 雷尼替丁枸橼酸铋 奥美拉唑 

分 类 号：R573.1[医药卫生—消化系统] R975.6[医药卫生—内科学]