二苯乙烯苷对Aβ25-35致NG108-15损伤的保护作用  

Protective effect of stilbene glucoside(TSG) on in NG108-15 cellular injury induced by Aβ25-35

作　　者：黄忠仕[1] 农嵩[1] 谢海渊[1] 张树球[1] 李韬[1] 李曙波[1] 

机构地区：[1]右江民族医学院生化教研室,广西百色533000

出　　处：《右江医学》2008年第5期517-519,共3页Chinese Youjiang Medical Journal

基　　金：广西教育厅资助项目(编号:桂教科200420-11)

摘　　要：目的观察二苯乙烯苷对Aβ25-35诱导损伤的NG108-15细胞生长、分化的影响。方法以Aβ25-35诱导NG108-15细胞建立痴呆细胞模型后加入二苯乙烯苷培养,观察NG108-15细胞的生长状态、存活率、突起率及突起平均长度。结果与细胞模型组相比,二苯乙烯苷组能在一定程度上抑制Aβ25-35对痴呆细胞的损伤作用,细胞生长状态良好,细胞存活率、突起率及突起平均长度与模型组比较均有显著性差异(P<0.05或P<0.01)。结论二苯乙烯苷对Aβ25-35诱导的NG108-15细胞损伤具有保护作用。Objective To observe the effects of TSG on the growth and differentiation of NG108-15 cells which were injured by Aβ25-35. Methods NG108-15 cells were cultured by Aβ25-35 to establish cell model of Alzheimer＇s disease fAD） and then were cultured with TSG. The growth state, survival rate, neurite outgrowth and average length of outgrowth of NG108-15 cells were observed. Results TSG could protect NG108-15 cells from Aβ25-35 damage. Compared with model group, the morphology, survival rate, neurite outgrowth and average length of outgrowth of NG108-15 cells were significant difference from TSG group （ P 〈0.05 or P 〈0.01）. Conclusion TSG can protect the NG108-15 cellular injury induced by Aβ25-35.

关 键 词：二苯乙烯苷 老年性痴呆 8淀粉样蛋白 NG108—15细胞 

分 类 号：R749.16[医药卫生—神经病学与精神病学]