组蛋白修饰酶对基因转录的调控  

Transcription Regulation by Histone-modifying Enzymes

作　　者：邢欣荣[1] 刘宇博[1] 程智逵[1] 伍会健[1] 

机构地区：[1]大连理工大学环境与生命学院,辽宁大连116024

出　　处：《生理科学进展》2008年第4期314-318,共5页Progress in Physiological Sciences

基　　金：国家自然科学基金(30670409;30771221);国家高技术发展计划(863计划)(2006AA02Z120)资助课题

摘　　要：基因在转录过程中,需招募多种组蛋白修饰酶来对组蛋白进行化学修饰,这些化学修饰包括:组蛋白的甲基化、乙酰化、磷酸化、泛素化和SUMO化等。大多数组蛋白修饰酶能与不同的转录因子形成复合物,并引起组蛋白和DNA之间相互作用的改变,从而调控基因的转录。本文总结了各种组蛋白修饰酶复合物的组成、结构及功能方面的研究进展。During gene transcription, it needs to recruit many histone-modifying enzymes to modify his- tone. These chemical modification contains methylation, acetylation, phosphorylation, ubiquitylation, sumoylation of histone and so on. Most of histone-modifying enzymes can form a complex with various transcriptional factors, they can change the interaction between histone and DNA, which regulate gene transcription. This review is focused on recent findings regarding the composition, the structure and the function of the histone-modifying enzyme complexes.

关 键 词：组蛋白修饰酶 基因转录 转录调控 

分 类 号：R73[医药卫生—肿瘤]