沿脑-肠轴探讨肠易激综合征的可能机制  

Discuss the Possible Mechanism of Irritable Bowel Syndrome along the Brain-gut Axis

作　　者：林艺娟[1] 王承党[1] 

机构地区：[1]福建医科大学附属第一医院消化内科,福州350005

出　　处：《医学综述》2008年第20期3138-3141,共4页Medical Recapitulate

摘　　要：肠易激综合征(IBS)是在特殊介质的基础上,以神经-内分泌-免疫系统为中介,以社会心理因素刺激为扳机而触发的心身疾病,迄今发病机制尚不明朗,内脏高敏感性作为其主要的最广为接受的病理生理机制备受瞩目,目前认为各种因素导致的外周和(或)中枢致敏是其重要的发病机制。本文综合近年来国内外学者的研究成果,从神经-内分泌-免疫网络失调这一角度探讨IBS患者内脏高敏感性的外周和中枢机制。Irritable bowel syndrome is psychophysiological disease triggered by social-physical factors, which is based on some special mediators and Nerve-endocrine-immunological network. The mech- anism of developing irritable bowel syndrome is still unclear. Visceral hypersensitivity is one of the most acceptable explanation. Most of those research focus on this area. Neither peripheral nor central sensiti- zation is thought to be significant pathogenesy at present. According to the recently achievement of re- search, we attempt to discuss the possible role of peripheraland central nerve-endocrine-immunologlcal network disfunction in the development of irritable bowel syndrome.

关 键 词：肠易激综合征 内脏高敏感性 脑-肠轴 神经-内分泌.免疫 

分 类 号：R574.4[医药卫生—消化系统]