前列腺疾患与前列腺癌关系研究的Meta分析  

Meta-ana lysis of prostate diseasesand prostata cancer

作　　者：胡俊丹[1] 胡云飞[1] 吴洋[1] 孙刚[1] 

机构地区：[1]武汉大学人民医院泌尿外科,武汉430071

出　　处：《临床泌尿外科杂志》2008年第9期667-670,共4页Journal of Clinical Urology

摘　　要：目的:探讨中国人群前列腺疾患(前列腺炎和前列腺增生)与前列腺癌的关系,为预防决策提供依据。方法:分别以"前列腺炎"、"前列腺增生"和"前列腺癌"等为检索词,收集1979年1月～2005年6月国内公开发表的关于中国人群前列腺疾患与前列腺癌的研究文献,并用RevMan 4.2软件对这些文献进行Meta综合定量;根据固定效应模型和随机效应模型计算结果的一致程度及失效安全系数进行敏感性分析。结果:纳入本次Meta分析的文献共有4篇,累计病例487例,对照1850例。前列腺疾患与前列腺癌发生的合并相对危险度(OR)值为4.69及95%可信区间(95%CI)为0.60～6.10,P<0.05。结论:前列腺炎、前列腺增生是前列腺癌发生的危险因素。Objective： To provide evidence for decision-making on prostatecancer prevention through investiga ring the relation between prostatitisbenign prostatic hyperplasiaand prostate cancerin chinese population. Methods： Using the searct; terms＂Prostatitis＂, ＂Benign prostatic hyperp lasia＂and＂Prostate cancer＂, the literature from Jan uary 1979 to June 2005 on the relationship between prostatitis,benign prostatic hyperp lasla and prostate cancer was searched from, and was studied by Meta analysis. At the same time, ORs of randomizedmodel and fixed mod el were calculated to evaluate the sensitivity. Results：Totally, 4epidemiologicalstudies on prostatitis, benign prostatic hyperp lasia and prostate cancer were analyzed synthetically by Meta analysis. The cumulative cases and con trois were 487 and 1850, respectively. The pooled odds ratio （OR） values and 95% CIs were as follows： Prostati t is, benign prostatic hyperp lasia 4.69 （0.60-6. 10）respectively （P〈0.05 for all）. Conclusions： Prostatitis, benign prostatic hyperplasiais the influncing factors of prostate cancer.

关 键 词：前列腺癌 前列腺炎 前列腺增生 META分析 

分 类 号：R737.25[医药卫生—肿瘤]