西南双生子登记系统：遗传因素与环境因素对儿童青少年行为发育及心理健康的影响研究  

A Prospective Twin Registry in Southwestern China： exploring the effects of genetic and environmental factors on cognitive and behavioral development and mental health well-being in children and adolescents

作　　者：黄颐[1] 高欣[1] 符一笑[2] 司徒明镜[1] 张小薇[1] 方慧[1] 张毅[1] 马小红[1] 王英成[1] 蒙华庆[2] 李涛[1] 

机构地区：[1]四川大学华西医院心理卫生中心,成都610041 [2]重庆医科大学附一院精神科

出　　处：《中华医学遗传学杂志》2008年第5期546-549,共4页Chinese Journal of Medical Genetics

基　　金：国家自然科学基金2005（30470625,30570654）志谢本研究在课题设计和资料分析过程中得到了英国伦敦大学精神病研究所遗传、社会发育研究中心的DavidCollier教授,遗传统计学教授Fruhling Rijsdijk的大力支持,在此表示感谢!

摘　　要：目的描述西南双生子登记系统的目的，样本收集方法，目前现状以及应用前景。研究遗传因素和环境因素对于儿童青少年行为、认知发育以及心理健康的影响。方法采用儿童自评、家长以及教师评定量表作为测量儿童行为和心理健康水平的工具，同时对儿童认知功能、家庭环境、儿童气质以及父母健康状况进行了测评，研究上述指标与儿童行为的相互关系以及遗传因素和环境因素的影响。结果目前已经登记了成都9339对0～16岁双生子，并对324对双生子进行了DNA卵型鉴定以及详细的行为和认知测评，并对遗传因素和环境因素对于儿童行为的相互影响进行了研究。结论学校途径招募双生子是进行儿童青少年双生子研究有效的途径。西南双生子登记系统可以为儿童行为发育以及儿童病理心理研究提供重要的国内和国际资源。Objective The goals, prospects and methods of the Prospective Twin Registry in Southwestern China （TRiSC） are described. The aim of this study is to measure children＇ s behavioral development and psychopathology from pbenotypic, genetic and environmental perspectives. Methods The children＇ s self-report, as well as parental and teachers＇ informant report were used to measure the children＇ s behavior and psychopathology, and the latter was related to the children＇ s general cognitive abilities, and to the parenting style. Other variables of interest such as children＇ s temperament and parental health status were also used. Results Nine thousand and three hundred thirty nine pairs of 0- 16 years old twins have been registered, 324 pairs of them were monozygotic based on DNA samples as well as the detailed information on behavioral and cognitive aspects. Analysis has been performed for the influences of genetic and environmental factors on children＇ s behavior and cognition. Conclusion School-based twins recruitment is a helpful method in child and adolescent twin study. TRiSC has been a valuable resource for research on the development of children＇ s behavior and cognition.

关 键 词：双生子登记系统 儿童行为发育 遗传学 

分 类 号：R686[医药卫生—骨科学]