过度使用互联网对事件相关电位N400的影响  

The Effect of Excessive Internet Use on N400 Event-related Potentials

作　　者：郁洪强[1] 赵欣[1] 汪曣[1] 李宁[1] 王明时[1] 

机构地区：[1]天津大学精密仪器与光电子工程学院生物医学工程与科学仪器系,天津300072

出　　处：《生物医学工程学杂志》2008年第5期1014-1020,共7页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30170308)

摘　　要：通过分析过度使用互联网患者与正常受试者事件相关电位N400的差异,找到过度使用互联网患者事件相关电位N400的特征,从而为过度使用互联网患者的诊断和治疗提供理论依据。对10名过度使用互联网患者(实验组)和10名正常受试者(对照组)分别进行单个汉字结尾笔画非匹配实验。结果表明,当单个汉字结尾笔画非匹配时,过度使用互联网患者所诱发出的N400与正常受试者所诱发出的N400相比较,潜伏期明显提前(P<0.05),波幅也明显降低(P<0.05),并且在对照组中所产生的N400其在大脑上的分布要比实验组中所产生的N400更加广泛。表明过度使用互联网患者与正常受试者的事件相关电位N400存在着显著性差异。This investigation was made on the characteristic of the N400 event-related potentials in excessive internet users by analyzing the N400 difference between the excessive internet users （trial team） and normal subjects （control team） ; the aim was to provide a theoretic basis for the diagnosis and treatment of excessive internet users. Ten righthanded excessive internet users and ten healthy right-handed volunteers aged 20 to 25 years were recruited to attend the experimentation of single Chinese character with semantically matching or mismatching ending strokes. The N400 dis- played obvious difference between the excessive internet users and normal subjects when they were confronted with mis- matching ending strokes of single simple Chinese character. The N400 amplitude of the trial team was significantly lower than that of the control team （P 〈 0.05）, and the N400 latency of the trial team was significantly earlier than that of the control team （P 〈 0.05 ）. In addition, the distribution of the N400 in the brain was more wide-spread in the control team than in the trial team. These results showed there was significant difference in N400 between the excessive internet users and the normal subjects.

关 键 词：单个汉字 过度使用互联网 N400 F300 

分 类 号：R749[医药卫生—神经病学与精神病学]