一种可生物降解温度敏感型聚乙二醇-聚己内酯-聚乙二醇水凝胶的合成和表征  

Synthesis and Characterization of Thermosensitive Hydrogel Based on PEG-PCL-PEG Block Copolymers

作　　者：巩长旸[1] 顾迎春[2] 谢震[3] 谢希惠 刘彩兵[4] 阚兵[1] 涂铭旌[4] 魏于全[1] 钱志勇[1] 

机构地区：[1]四川大学华西医院肿瘤生物治疗国家重点实验室,成都610041 [2]四川大学纺织系,成都610065 [3]江苏省姜堰市中医院,姜堰225500 [4]四川大学材料科学与工程学院,成都610065

出　　处：《生物医学工程学杂志》2008年第5期1121-1125,共5页Journal of Biomedical Engineering

基　　金：四川省科技攻关项目资助课题(06(05SG022-021-02))

摘　　要：合成了一系列分子量较低的聚乙二醇-聚己内酯-聚乙二醇(Poly(ethylene glycol)-Polycaprolactone-Poly(ethylene glycol),PEG-PCL-PEG)三嵌段共聚物。分别采用FTIR和1H-NMR对其结构进行了表征。所合成的PEG-PCL-PEG共聚物具有良好的水溶性,当水溶液浓度高于临界凝胶浓度(Critical gel concentration,CGC)时,随着温度的变化聚合物水溶液会呈现特有的凝胶-溶胶转变。研究了共聚物亲水疏水链段的比例和长度,以及热历史等对凝胶-溶胶转变行为的影响。通过调节上述条件,可以在一定程度上拓宽凝胶-溶胶转变温度范围,有助于PEG-PCL-PEG水凝胶在可注射药物控制释放系统等方面的应用。In this paper, a series of low-molecular-weight PEG-PCL-PEG triblock copolymers were successfully syntbesized by ring-opening polymerization method, and were characterized using 1H-NMR and FTIR. The aqueous solution displayed specific therrnee, ensitive gel-sol transition when the concentration was above corresponding critical gel concentration （CGC）. The gel-sol phase diagram was recorded using test tube-inverting method, which was depended on the hydrophilic/hydrophobie balance in macromolecular structure, as well as heating history. As a result, the gel-sol transition temperature range could be altered, which might be very useful for its application as injectable drug delivery system.

关 键 词：聚己内酯-聚乙二醇共聚物 可生物降解 温度敏感 水凝胶 

分 类 号：R318.08[医药卫生—生物医学工程]