抗狂犬病病毒中和活性单克隆抗体对狂犬病街毒暴露后的治疗  

Anti-rabies Virus Neutralizing Monoclonal Antibody in Post-exposure Treatment of Rabies

作　　者：汪霞[1] 唐建蓉[2] 吴杰[1] 郑新雄[1] 祝玉桃[1] 张智[1] 董关木[2] 张永振[3] 徐葛林[1] 

机构地区：[1]武汉生物制品研究所,湖北武汉430060 [2]中国药品生物制品检定所,北京100050 [3]中国疾病预防控制中心传染病预防控制所,北京102206

出　　处：《中国疫苗和免疫》2008年第5期426-429,共4页Chinese Journal of Vaccines and Immunization

摘　　要：目的研究鼠抗狂犬病病毒中和活性单克隆抗体(单抗)2C、5C,对狂犬病街毒暴露后的治疗效果。方法用3个街毒代表株CQ92、HN06、GX-4分别感染Balb/c小鼠腓肠肌,30min后用2C、5C、狂犬病人免疫球蛋白(Hu-man Rabies Immunoglobulin,HRIG)进行治疗。结果2C、5C、HRIG对狂犬病街毒暴露后小鼠具有相近的保护率。结论鼠抗狂犬病病毒中和活性单抗可用于狂犬病病毒暴露后的治疗。Objective To study the Protection of neutralizing mouse monoclonal antibodies against rabies virus（2C and 5C）after exposure street rabies virus.Methods Balb/c mice were exposure with street rabies virus of CQ92、HN06 or GX-4 strains respectively,which were main strain of virus in China and infected,in the gastrocnemius muscle.All the mice were administered with 2C、5C or human rabies immune globulin（HRIG） 30 min after exposure respectively.Results Mouse monoclonal antibodies against rabies glycoprotein（2C、5C）had same protection against street rabies virus challenge with HRIG in mice.Conclusion 2C and 5C were potential therapeutic antibodies in rabies post-exposure treatment.

关 键 词：狂犬病病毒 中和活性单克隆抗体 治疗 

分 类 号：R186[医药卫生—流行病学] R512.99[医药卫生—公共卫生与预防医学]