乙肝患者血清IL-2、sIL-2R水平与肝损程度、HBV DNA含量的变化  

The detection of serum IL-2,sIL-2R levels,and liver damage degree,HBV DNA content in hepatitis B patients

作　　者：李俐[1] 张家颖[1] 刘剑凯[2] 杨成君[2] 吴山力[2] 马颖哲[2] 

机构地区：[1]吉林大学白求恩医学院生物化学与分子生物学中心,吉林长春130021 [2]吉林大学白求恩医学院生物化学教研室

出　　处：《中国老年学杂志》2008年第19期1883-1884,共2页Chinese Journal of Gerontology

基　　金：国家自然科学基金课题资助(30570688)

摘　　要：目的探讨乙型肝炎患者血清IL-2、sIL-2R含量与肝损程度和HBV DNA含量的相关性及临床意义。方法收集急、慢、重型乙肝患者血清标本共93例,28例健康人血清标本作为对照组,采用ELISA法检测各型乙型肝炎患者血清中IL-2、sIL-2R。HBV DNA定量采用荧光定量PCR法。结果各型乙肝患者血清中IL-2均有所下降,sIL-2R均高于正常对照组(P<0.05),并随肝损伤程度加重,含量随之增加。慢性肝炎患者血清sIL-2R水平与HBV DNA含量呈正相关系。结论乙型肝炎患者血清IL-2、sIL-2R水平及HBV DNA含量可作为判断感染乙肝病毒后机体免疫水平和细胞受损程度的参考指标。Objective To explore the relationship between blood serum IL-2, sIL-2R contents and liver damage degree and HBV DNA content of hepatitis B patients and the clinical significance. Methods The blood serum specimen of 93 cases of acute, or chronic hepatitis, or heavy hepatitis B and 28 healthy persons were obtained to examine serum IL-2, sIL-2R. HBV DNA quota by ELISA and fluorescent quantitation PCR method. Results In each blood serum IL-2 level dropped, sIL-2R level in hepatitis group was higher than that of normal control group （P 〈 0.01 ） and along with liver extent of damage aggravation. Serum sIL-2R level and HBV DNA content presented positive correlation. Conclusions After infection of hepatitis B virus, hepatitis B patients＇ serum IL-2, sIL-2R level and HBV DNA content may be as organism immunity level and the judgment cell damage degree norm for reference.

关 键 词：乙型肝炎 HBV DNA 白细胞介素 

分 类 号：R-332[医药卫生]