转移抑制基因KAI1在原发肝癌中的表达及其临床意义  

Expression of Metastasis Suppressor Gene Kail in Primary Liver Cancers and Their CIinicopath010gicaI Characteristics

作　　者：吴波[1] 翟哲[1] 陈曦海[1] 

机构地区：[1]哈尔滨医科大学附属四院普外科,黑龙江哈尔滨150001

出　　处：《中国伤残医学》2008年第5期14-15,共2页Chinese Journal of Trauma and Disability Medicine

基　　金：黑龙江省教育厅科学技术研究项目;项目编号:10551212

摘　　要：目的:检测转移抑制基因Kail的蛋白表达,探讨其与原发肝癌生物学行为的关系。方法:采用免疫组化sP法分别测定了53例肝癌、17例正常肝脏新鲜冰冻组织中Kail蛋白的表达。结果:53例原发肝癌中19例(36%)Kail蛋白表达阳性,与正常肝脏(82%)相比,差异有显著性(P<O.01)。早期肝癌Kail蛋白表达率明显高于中,晚期肝癌(P<O.05)。巨块癌Kail表达率高于结节癌(P<O.01)。癌细胞分化程度I、II级肝癌Kail表达率明显高于晚期III、Ⅳ级(P<O.05)。结论:Kail蛋白表达下降可能预示转移,且于肝癌恶性程度有关,可成为判断预后的因素之一。Objective：To explore the expression of metastasis suppressor geneKai 1 in primary liver cancers and its relationship to clinicopathological feature. Methods： The expression of Kai 1 protein in fresh freezing tissures from 53 primaryJiver cancer patients, 1 7 normal were examined by immuno-histochemistry SP method. Results：Kai 1 expression was observed in 1 9 of 53 primary liver cancers（36%,and in14 of 17 norl～ alliver（82%）, the latter iS higher（P〈0. 01）. It was significantly higher inearly stage than that in late stage tumors（P〈0. 05）. Serous liver cancers showed significantly decreased staining of Kail when compared （p〈0.01）. Furthermore, Kai 1 expression in atypia（Ⅰ, Ⅱ）was higher than thatinⅢ, Ⅳ （P〈0. 05）. Conclusion： The dowrtregulafion of Kai 1 may indicaternetastasis, and relate with malignant degree of liver cancer. It could be used newprognostic marker of C primary liver ancer.

关 键 词：原发肝癌 Kail蛋白 转移 

分 类 号：R735.7[医药卫生—肿瘤]