高脂日粮中n-6、n-3脂肪酸配比对小鼠机体抗氧化能力及血脂的影响  

Different ratio of n-6/n-3 PUFA effect on the anti oxidation and the blood fat metabolism in high fed diet mices

作　　者：岳鹏[1] 乐国伟[1] 杨瑞丽[1] 王姣[1] 施用晖[1] 

机构地区：[1]江南大学食品科学与技术国家重点实验室,无锡214122

出　　处：《食品科技》2008年第10期257-260,共4页Food Science and Technology

基　　金：自然科学基金项目(30571347)

摘　　要：为了了解不同n-6、n-3系多不饱和脂肪酸配比对小鼠机体抗氧化能力和血脂的影响,通过测定饲喂6周不同饲料C57小鼠血浆中总抗氧化能力(T-AOC)、超氧化物岐化酶(SOD)、丙二醛(MDA)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)和致动脉粥样硬化指数(AI)并进行统计分析。实验结果表明,从改善血脂、提高机体抗氧化能力来看,n-6、n-3不饱和脂肪酸比例10:1组效果好于5:1组,若添加抗氧化剂LA,有利于改善机体脂质过氧化产生的不良影响,对预防动脉粥样硬化会起到积极的作用。The present paper mainly studies the different ratios between the n-6 polyunsaturated fatty acid （PUFA） and the n-3 PUFA in high energy diet C57 mices effect on the blood fat metabolism and the capability of anti oxidation. Test the level of the total anti-oxidation capability（T-AOC）, superoxide dismutase（SOD）, the malonaldehyde（MDA）, the total cholesterol（TC）, the triglyceride（TG）, the high density lipoprotein-cholesterol （HDL-C）, the low density lipoprotein-cholesterol（LDL-C） and the atherosclerotic index（Al）. Both the 5：1 and 10：1 mixture ratio oil has the effects on anti-oxidation and reducing the lipid peroxidation, clear the free radical, the capability changes following the ratio of n-6 and n-3 PUFA. According to this experiment, the ratio of 10：1 is better than 5：1 in both anti-oxidation and reducing the lipid peroxidation, especially in reducing the lipid perixidation. And with the help of the anti-oxidant LA, it could be more effect in cleaning free radical and prevent the atherosclerotic.

关 键 词：n-6 n-3 LA抗氧化 脂质过氧化 

分 类 号：TS201.4[轻工技术与工程—食品科学]