Effect of Electroacupuncture on Experimental Epilepsy: Roles of Different Acupoints and Stimulation Parameters  

作　　者：康学智 夏萤 

机构地区：[1]Shanghai Research Center of Acupuncture and Meridian,Shanghai 201203,P.R.China [2]Shanghai Research Center of Acupuncture and Meridian,Shanghai 201203,P.R.China Yale University School of Medicine,New Haven,CT,USA

出　　处：《Journal of Acupuncture and Tuina Science》2008年第5期279-280,共2页针灸推拿医学（英文版）

基　　金：the Science Foundation of Shanghai Municipal Commission of Science and Technology(05DZ19745,06DZ19732,064319053,07DZ19722,07DZ19733);the National Basic Research Program of China(973 Program,2005CB523306);Shanghai Leading Academic Discipline Project(B112 and T0302);NIH-HD3485

摘　　要：Objective： The strategies against epilepsy are currently very limited. The author performed this work to determine the effect of electroacupuncture （EA） on epileptic seizures and define the optimal EA conditions （acupoints and stimulation parameters）. Methods： Experimental epilepsy was induced by injecting kainic acid into the lateral cerebral ventricle of adult male SD rats. EA with a current of 1 mA/100 Hz or 1 mA/10 Hz was applied to the model starting at 0.5 h after the injection for 30 rain. Four pairs of acupoints were tested, including Renzhong （GV 26） ＋ Dazhui （GV 14）, Jinsuo （GV 8） ＋ Yaoqi （Ex-B 9）, Neiguan （PC 6） ＋ Quchi （LI 11） and Fenglong （ST 40） ＋ Yongquan （KI 1）. Results： Behavioral scores showed that （1） either high （100 Hz） or low （10 Hz） frequency EA at different acupoints attenuated epileptic seizures （P〈0.05 or 0.01 vs. the control）, except EA at Neiguan （PC 6） ＋ Quchi （LI 11） with 1 mA/10 Hz current; （2） EA with low frequency stimulation （10 Hz） induced a better effect at Fenglong （ST 40） ＋ Yongquan （KI1） than other acupoints （P〈0.05 or 0.01）; （3） there was no significant difference in EA effects induced by various acupoints when exposed to high frequency EA （100 Hz）; and （4） high frequency EA （100 Hz） elicited a better effect than low frequency EA （10 Hz） in all groups （P〈0.05 or 0.01） except for that of Jinsuo （GV 8） ＋ Yaoqi （Ex-B 9）. EEG showed the similar tendency, i.e., EA generally reduced the amplitude and frequency of epileptic discharges. Conclusion： Electroacupuncture attenuates epileptic seizures, which is relatively specific to EA parameters and acupoints.目的:确定电针对实验性癫痫的抑制效应,探索治疗实验性癫痫的最佳电针条件。方法:在雄性 SD 大鼠侧脑室注射红藻氨酸以诱导急性实验性癫痫。造模30分钟后,以1 mA/100 Hz 和1 mA/10 Hz 电针分别在水沟+大椎、筋缩+腰奇、内关+曲池、丰隆+涌泉四组穴位施治,以 Racine 行为学评分和脑电记录作为疗效评价的方法。结果:行为学评分结果表明:除1 mA/10 Hz 电针内关+曲池外,低频(10 Hz)和高频(100 Hz)电针均可抑制实验性癫痫的发作(和对照组比较 P<0.05或0.01);2)在低频电针(10 Hz)治疗组中,丰隆+涌泉穴位的治疗效果优于其他穴位组(P<0.05或0.01);3)高频电针(100 Hz)治疗组中,不同穴位之间的疗效差异不明显;4)总体而言,除筋缩+腰奇穴位组外,高频电针(100Hz)的治疗效果优于低频电针(10 Hz)(P<0.05或0.01)。与此同时,脑电图记录也显示出电针具有降低实验性癫痫大鼠脑电频率和幅度等的作用。结论:电针可以减轻实验性癫痫大鼠的癫痫发作,其效应与电针参数和穴位的选择有一定的相关性。

关 键 词：EPILEPSY ELECTROACUPUNCTURE Acupuncture Points 

分 类 号：R2-03[医药卫生—中医学]