β-环糊精与佐匹克隆包合作用的研究  

Study on Inclusion Complexes of β-Cyclodextrin with Zopiclone

作　　者：陈圆圆[1] 刘佳佳[1] 唐课文[1,2] 

机构地区：[1]中南大学化学化工学院,湖南长沙410083 [2]湖南理工学院化学化工系,湖南岳阳414000

出　　处：《光谱学与光谱分析》2008年第10期2380-2383,共4页Spectroscopy and Spectral Analysis

基　　金：国家自然科学基金项目(20376085);中国博士后科学基金项目(2004035650)资助

摘　　要：采用相溶解度法研究了佐匹克隆在不同pH和不同摩尔浓度的β-环糊精水溶液中的溶解度及二者的表观稳定常数,随着β-环糊精浓度的增加和pH的提高,佐匹克隆的溶解度增加,表观稳定常数升高;采用热力学方法研究了温度对包合反应的影响,计算了包合过程的熵变ΔS、焓变ΔH及自由能变化ΔG均为负值,说明包合反应是放热反应且能自发进行,焓变是形成超分子复合体的主要驱动力;用研磨法制备了佐匹克隆-环糊精包合物,并用红外光谱和差示扫描量热分析对固体包合物进行了表征。结果表明,佐匹克隆与β-环糊精可形成1∶1包合物,β-环糊精对于难溶性药物佐匹克隆是较理想的增溶剂。The inclusion complex formation of zopielone with β-yclodextrin was studied by using phase solubility method, and the formation constant for zopiclone -β-cyclodextrin was determined. The solubility of zopiclone and the formation constant were enhanced with the increase in ffcyclodextrin concentration and pH. The effect of temperature on .the reaction was studied through thermodynamics, and the changes in entropy ΔS, enthalpy ΔH and free energy ΔG of the reaction were all negative, suggesting that the inclusion complexation is exothermic and can spontaneously occur by the balance of enthalpy driving and entropy opposing. The inclusion complex of zopiclone and β-cyclodextrin was prepared by a method of solidgrinding,Stable inclusion complex in solid state was characterized by IR spectra and DTA. Results showed that zopiclone-β-cyclodextrin conclusion complex could be formed, and β-cyclodextrin is a desirable solubilizer for zopiclone.

关 键 词：Β-环糊精 佐匹克隆 相溶解度法 包合物 热动力学 

分 类 号：O657.3[理学—分析化学]