光动力学疗法对大鼠W256移植瘤的生长和GSH—PX活性的影响  

Effects of photodynamic therapy on the growth of W256 transplant tumor and glutathione peroxidase activity in rats

作　　者：崔瑞耀[1] 沈芳臻[2] 徐珞[1] 陶尚敏[1] 王玉贞[1] 夏冰 陈维刚[2] 

机构地区：[1]青岛医学院病理生理学教研室,青岛266021 [2]青岛医学院附院肿瘤科,青岛266021

出　　处：《中国病理生理杂志》1997年第6期635-637,共3页Chinese Journal of Pathophysiology

基　　金：山东省自然科学基金

摘　　要：用先动力学疗法（photodynamicgherapy.PDT）对W256移植瘤进行治疗，并观察W256移植瘤的生长速度和检测大鼠血和肝组织中谷胱甘肽过氧化物酶（GSH—PX）的活性。结果如下：①接受PDT治疗组大鼠W256移植瘤生长缓慢（P＜0.05）②接受PDT治疗组大鼠血和肝组织中的GSH-PX活性显著低于肿瘤对照组大鼠(P＜0.01)；而肿瘤对照组大鼠血和肝组织中的GSH-PX活性又显著低于正常对照组大鼠(P＜0.05，P＜00.1)。提示PDT对肿瘤生长有抑制作用。The effects of photodynamic therapy (PDT) on the rats with W256 transplant-tumor were studied. It was found that the tumor grew slower (P<0.05) and the activity of glutathione peroxidase (GSH-PX) in blood and liver tissue was lower (P<0.01) in PDT group than that of the tumor control group, which was in turn than that of the normal control group (P<0.05,p<0.01). These results suggested that PDTmay have an suppressive effect on the growth of transplant-tumor.

关 键 词：大鼠 肿瘤 光动力学疗法 GSH-PX 

分 类 号：R73－36[医药卫生—肿瘤]