27例三氧化二砷严重不良反应病例报告分析  

Analysis of 27 Cases on Serious Adverse Drug Reaction Induced by Arsenic Trioxide

作　　者：甘戈[1] 孙骏[1] 王佳域[1] 王越[1] 

机构地区：[1]江苏省药品不良反应监测中心,江苏南京210002

出　　处：《中国药物警戒》2008年第5期286-290,共5页Chinese Journal of Pharmacovigilance

摘　　要：目的了解三氧化二砷严重不良反应的特点,为临床使用提供参考。方法通过检索1994～2007年《中国期刊全文数据库》,对收集到的27例三氧化二砷严重不良反应的文献报道进行统计分析。结果三氧化二砷所致严重不良反应累计多个系统-器官,其中分别导致心、肝、肾功能衰竭的例数分别为13例、6例、3例,占23.2%、10.71%、5.38%;全身严重水肿5例,导致死亡9例。严重不良反应多发生在用药2周内。结论应加强对三氧化二砷所致严重不良反应的研究及再评价。Objective To investigate the characteristics of serious adverse drug reacdon（ADR）induced by arsenic trioxide（As2O3）. Methods 27 cases of serious ADR induced by As203 were searched from Chinese Journal Full-text Database between 1994 and 2007. Results The serious ADR of As203 in-volved several systems-organs, causing the number of the heart, liver, kidney function failure respectively was 13,6,3, having 23.2%, 10.71%, 5.38% respectively, the whole body severity edema was 5, causing 9 death. Most serious ADR happened in two weeks. Conclusion It should be strengthening the observation and evaluation of As2O3.

关 键 词：三氧化二砷 药品不良反应 急性早幼粒细胞白血病 

分 类 号：R916.696[医药卫生—药学] R994.11