慢性肝病与肝癌患者性激素水平变化的临床意义  

A stduy on the clinical significance of gonadal hormone changes in serum in patients with different clinic type chronic hepatic disease and hepatocellular carcinoma

作　　者：陈永胜[1] 关丽[2] 邱冰[1] 段立伟[1] 田月丽[1] 李东复[1] 

机构地区：[1]吉林大学第二医院消化内科,吉林长春130041 [2]吉林大学中日联谊医院

出　　处：《中国实验诊断学》2008年第10期1233-1234,共2页Chinese Journal of Laboratory Diagnosis

基　　金：吉林省科技厅基金资助课题(2006416-4)

摘　　要：目的探讨性激素变化与慢性肝病、肝癌发生发展的关系。方法应用放免分析法对128例慢性肝病(慢性肝炎92例、肝炎肝硬化23例、肝硬化并发肝癌13例血清中睾酮(T)、雌二醇(E2)和催乳素(PRL)等进行了测定。结果慢性肝炎重度、肝硬化、肝硬化并发肝癌各组血清T含量明显低于慢性肝炎轻度组及正常对照组(P<0.05);血清E2含量与慢性肝病、肝癌及正常对照组间比较无明显差异(P>0.05),但是,随着慢性肝炎向肝硬化、肝癌进展,慢性肝炎重度、肝硬化、肝硬化并发肝癌各组血清E2/T、E2/PRL水平明显高于慢性肝炎轻度组及正常对照组(P<0.05;P<0.01)。结论慢性肝病T水平降低及E2、PRL水平升高与肝功能损害程度相关。Objective To investigate the clinical significance of gonadal hormone changes in patients with different clinical type chronic hepatic disease and hepatocellular carcinoma. Methods Testosterone （T）,estradiol （E2） and pmlactin （PRL） in serum were measured by radio immunity assay in Patients with different clinical type chronic hepatic disease and hepatocellular carcinoma. Results There were a significant reduction in T, a significant elevation in PRL and E2/T of patients with chronic severe hepatitis, hepatocirrhosis,hepatocellular carcinoma groups than in control group （ P 〈 0.05, P 〈 0.01 ）,and no significant changes in E2. Con- dusion There was disorder in levels of gonadal hormone of patients with different clinical type chronic hepatic disease and hepatocel- lular carcinoma. T, E2 and PRL levels were related to liver function lesion degree in patients with different clinical type chronic hepatic disease and hepatocellular carcinoma.

关 键 词：慢性肝病 肝硬化合并肝癌 性激素/睾酮 雌二醇 催乳素 

分 类 号：R575[医药卫生—消化系统] R735.7[医药卫生—内科学]