应用公式计算A型肉毒毒素剂量缓解脑瘫小腿三头肌痉挛的对照研究  

Releasing Spasticity of Triceps Surae Muscle of Children with Spastic Cerebral Palsy by Botulinum Toxic A Block with Dose Calculated According to Certain Formula

作　　者：刘建军[1] 纪树荣[1] 胡莹媛[1] 吴卫红[1] 李燕春[1] 陆华宝[1] 张雁[1] 

机构地区：[1]首都医科大学康复医学院

出　　处：《中国康复理论与实践》2008年第10期956-957,共2页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的探讨应用公式计算A型肉毒毒素(BTX-A)使用剂量是否可以提高疗效、延长疗效持续时间。方法15例脑瘫患儿为试验组,按照公式计算BTX-A使用剂量进行缓解痉挛治疗。58例患儿作为对照组,按常规方法确定BTX-A剂量。结果治疗后,试验组患儿下肢功能提高的幅度大于对照组(P<0.05),疗效持续时间显著长于对照组(P<0.001)。结论应用公式计算BTX-A剂量可以提高疗效,延长疗效持续时间。Objective To investigate whether the curative effect of Botulinum Toxic A （BTX-A） block increased and prolonged when the dose calculated according to certain formula. Methods 15 children with cerebral palsy （CP） were appointed as the trial group and the dose of BTX-A was calculated according to the designed formula. The other 58 CP children were appointed as the control group and the BTX A dose was determined by routine method. Results After treatment, the motor function of the children in tri al group was superior to that in the control group （P〈0.05） and the duration of therapeutic effect of the trial group was significantly longer than the control group （P〈0. 001）. Conclusion BTX-A dose calculated according to the formula can increase effect and prolong the duration.

关 键 词：脑性瘫痪 痉挛 A型肉毒毒素 神经阻滞 剂量 

分 类 号：R742.3[医药卫生—神经病学与精神病学]