抑郁症中医辩证与前额叶及海马^1H-MRS的相关性探讨  

Relativity between Changes of 1H-MRS in Hippocampus and Prefrontal Lobe and the Syndrome Differentiation of Major Depression

作　　者：段冬梅[1] 图娅[2] 陈利平[1] 吴整军[1] 

机构地区：[1]解放军总医院中医针灸科,北京市100853 [2]北京中医药大学针灸学院,北京市100029

出　　处：《中国康复理论与实践》2008年第10期960-962,共3页Chinese Journal of Rehabilitation Theory and Practice

基　　金：北京市自然科学基金重点项目(No.7051003)

摘　　要：目的探讨抑郁症中医辨证分型与前额叶及海马磁共振氢质子波谱(1H-MRS)变化的相关性。方法随机选取60例抑郁症患者,辨证分型为A组(痰热型)、B组(瘀血型)、C组(虚热型)、D组(寒湿型)四型,应用三维磁共振氢质子波谱(3D1H-MRS)检查,并分别与20例健康者对照,比较双侧前额叶背外侧白质和海马组织氮-乙酰天门冬氨酸(NAA)/胆碱(Cho)、NAA/肌酸(Cr)和Cho/Cr的比值。结果A、C组双侧前额叶Cho/Cr与对照组的差异有显著性意义(P<0.05);B、C、D三组双侧海马NAA/Cr与对照组的差异有显著性意义(P<0.05)。结论抑郁症患者前额叶、海马部位的相关生化物质代谢改变与不同中医证型有一定相关性。Objective To explore the relativity between the changes of ^1H magnetic resonance spectroscopy （^1H MRS） in hippocampus and prefrontal lobe and syndrome differentiation of major depression. Methods Sixty patients with major depression （MD） were divided into Group A （phlegm-heat syndrome）, Group B （blood stasis syndrome）, Group C （deficient fire syndrome） and Group D （cold-dampness syndrome）, and other 20 normal controls were selected. The neurochemical abnormalities including the ra tios of N-acetylaspartate （NAA）/choline （Cho）, NAA/creatine （Cr） and Cho/Cr were measured with three-dimension ^1H proton magnetic resonance spectroscopy （3D^1 H-MRS）. Results The ratios of Cho/Cr in white matter of the prefrontal lobe were significant higher in MD patients than that in normal controls （P〈0.05） ; the ratios of NAA/Cr in hippoeampus were significant higher in MD patients than that in normal controls （P〈0.05）. Conclusion There might be the relativity between the neurochemical abnormalities in hippocampus and prefrontal lobe and traditional Chinese medicine syndrome differentiation of major depression.

关 键 词：辨证 磁共振波谱 前额叶 海马 抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]