肝炎肝硬化患者血清肿瘤坏死因子-α及纤维化指标测定的临床意义  

Clinical Significance of Determination of Serum TNF-α,HA,PCⅢ and ⅣC in Cases with Cirrhosis After Hepatitis

作　　者：张平[1] 刘娅[1] 袁爱杰[1] 袁迎春[1] 

机构地区：[1]宁夏医学院附属医院感染性疾病科,银川750004

出　　处：《宁夏医学院学报》2008年第5期565-566,572,共3页Journal of Ningxia Medical College

摘　　要：目的了解肿瘤坏死因子-α(TNF—α)及纤维化指标(HA、PCⅢⅣC)在肝硬化肝功能损害中的临床意义。方法采用放射免疫分析法测定了52例肝炎后肝硬化患者(观察组)和28例慢性肝炎(对照组)患者血清TNF-α和血清HA、PCⅢⅣC的变化。结果观察组52例患者血清中TNF-α浓度明显增高,与对照组比较差异有统计学意义(P<0.01);观察组HA、PCⅢ、ⅣC水平明显高于对照组(P<0.01)。TNF—α与Child- Pugh分级无关(P>0.05)。结论提示TNF—α、HA、PCⅢⅣC在肝硬化病程进展中起一定作用。Objective To explore the effect of Serum TNF-α,HA,PCⅢ and IVC in cases with with Cirrhosis after hepatitis. Methods The serum concentration of TNF-α in 52 cirrhosis cases with a history of hepatitis and in 28 chronic viral hepatitis patients were determined with mdioimmunological assay methods.Results Serum TNF-α, HA,PCⅢ and IVC in 52 cirrhosis cases were significantly higher than those in 28 chronic viral hepatitis patients. Conclusion TNF-α,HA,PCⅢ IVC play an important role in the pathogeness of liver fibrosis.

关 键 词：肝炎 肝硬化 肿瘤坏死因子 透明质酸 Ⅲ型前胶原 Ⅳ型胶原 

分 类 号：R575.2[医药卫生—消化系统]