^(211)At-Te 胶体的体内行为及其实验肿瘤治疗  

Behaviour in vivo and experimental tumour therapy of 211 At-Te colloid

作　　者：金建南[1,2] 王喜忠[1,2] 张淑渊 刘宁 许道权[1,2] 陈文元 周懋伦 

机构地区：[1]四川联合大学原子核科学技术研究所 [2]四川联合大学

出　　处：《核技术》1997年第11期671-675,共5页Nuclear Techniques

摘　　要：制备了粒径３—８μｍ的２１１Ａｔ－Ｔｅ胶体。测定、比较了２１１Ａｔ－Ｔｅ胶体和游离２１１Ａｔ在小鼠体内的分布，表明了２１１Ａｔ－Ｔｅ胶体的稳定性，但是在体内条件下，会发生一定程度的脱砹作用。２１１Ａｔ－Ｔｅ胶体对小鼠艾氏腹水瘤的治疗作用研究显示，经腹腔单次注射１ＭＢｑ或２ＭＢｑ的胶体，均能治愈荷瘤小鼠，且对正常组织、器官没有明显的毒副作用；低于治愈剂量治疗，能延长小鼠存活时间，在３ＭＢｑ较高剂量下，小鼠则因毒性而死亡。? 211At-Te colloid with a diameter of 3—8μm was prepared. The biodistribution of  211At-Te colloid and free 211 At in mice were measured and compared. The stability of 211 At-Te colloid was confirmed, but under in vivo conditions some degree of deastatination had occured. The therapeutic effect of 211 At-Te colloid for Ehrlich ascites tumors in mice was investigated. The result showed that tumor can be cured in all mice that received a single intraperitoneal injection of 1 or 2 MBq 211 At-Te colloid, without causing undue toxic side effects to normal tissues. Below these curative doses, the survival time of mice was prolonged. The mice died away due to toxicity after injection of doses over 3 MBq.

关 键 词：放射性胶体 生物分布 辐射治疗 腹水瘤 碲 砹211 

分 类 号：R73－36[医药卫生—肿瘤] R730.55[医药卫生—临床医学]