CXCR4-CXCL12轴在肺癌中的表达及临床意义  

The Expression and Significance of CXCR4-CXCL 12 Biological Axis in Human Lung Cancer

作　　者：吴继[1] 白冰[1] 徐振晔[1] 赵晓珍[1] 许能[1] 

机构地区：[1]上海中医药大学附属龙华医院,上海200032

出　　处：《实用中西医结合临床》2008年第5期1-2,共2页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

基　　金：上海市重点学科建设资助项目(Y0302)

摘　　要：目的:探讨CXCR4-CXCL12轴在肺癌中的表达及临床意义。方法:选择发生或不发生纵隔淋巴结转移的肺癌组织各20例,通过免疫组化法分别检测肺癌组织中CXCR4的蛋白表达、淋巴结组织中CXCL12的蛋白表达。结果:发生淋巴结转移的肺癌组织中CXCR4蛋白的表达水平要高于不发生淋巴结转移的肺癌组织,而有癌浸润的淋巴结组织中CXCL12表达水平与无癌浸润的淋巴结中CXCL12水平相似;CXCR4的表达与肺癌患者的性别、年龄、肿瘤组织学类型和分化程度等无关,而与肺癌患者有无纵隔淋巴结转移有关。结论:CXCR4在肺癌组织中的高表达与淋巴结转移有关。Objective：To investigate the expression and significance of CXCR4-CXCL12 biological axis in human lung cancer. Methods： 20 lung cancer specimens with mediastinum lymph node metastasis and 20 lung cancer specimens without lymph node mediastinum metastasis were chosen. Immunohistochemistry was preformd to detect the expression of CXCR4 protein on tumor specimens and CXCL12 protein on lymph node. Result： Lung cancer specimens with mediastinum lymph node metastasis showed higher level of CXCR4 protein compared with tumor tissue without metastasis. However CXCL 12 expression of positive lymph node tissue was similar with that of negative lymph node. CXCR4 expression was independent of the patient＇s age,gender, pathological type and histological grade.CXCR4 tended to be detected in the tumor specimens with lymph node metastasis. Conclusion： High-level expression of CXCR4 was associated with lung cancer with mediastinum lymph node metastasis.

关 键 词：肺癌 CXCR4-CXCL12轴 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤]