胸腔积液中粘蛋白1表达的临床意义  

Clinical Significance of MUC1 Expression in the Pleural Effusion

作　　者：周龙[1] 李瑶[1] 熊国亮[1] 雷建平[1] 

机构地区：[1]江西省胸科医院,南昌330006

出　　处：《实用中西医结合临床》2008年第5期52-53,共2页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

基　　金：江西省卫生厅资助课题(审批号20041143)

摘　　要：目的:评价MUC1mRNA在非小细胞肺癌患者和非肿瘤患者胸腔积液中表达的临床意义。方法:应用逆转录聚合酶链反应(RT-PCR)技术,对30例肺癌患者、20例非肿瘤患者的胸腔积液中的MUC1mRNA表达进行检测。结果:非肿瘤患者的胸腔积液中未检测到MUC1mRNA的表达。肺癌患者胸腔积液中MUC1mRNA的敏感性为30%(9/30),特异性为100%。胸腔积液中MUC1mRNA的表达与肺癌组织类型密切相关,P<0.05;与患者年龄、性别、吸烟与否,肿瘤生长部位无明显相关,P>0.05。结论:应用RT-PCR法检测肺癌患者胸腔积液中MUC1mRNA的表达,具有一定的临床参考价值。Objective： To evaluate the clininal significance of MUC1 mRNA expression in the pleural effusion of non-small cell lung cancer patients and non-cancer patients.Methods： Using RT-PCR to detect MUC1 mRNA expression in the pleural effusion in 30 patients with lung cancer, 20 patients with non-cancer .Results： MUC1 mRNA expression were found in the pleural effusion in 9/30 patients with lung cancer, and not found in non-cancer patients. Sensitivity of MUC1 mRNA expression were 30%（9/30）, Specific of MUCI mRNA expression were 100%. MUC1 mRNA expression in the pleural effusion was closely related to cell differentiation of cancer, P〈0.05,but was not related to age, sex, smoking or not, site of tumor,P 〉0.05.Conclusions： MUC1 mRNA expression may be found with RT-PCR method in the plenral effusion of non-small cell lung cancer patients,it has a clinical reference value.

关 键 词：癌 粘蛋白类 基因表达 胸腔积液 

分 类 号：R734.2[医药卫生—肿瘤]