4,5-二氯邻苯二甲腈的合成  

Synthesis of 4,5-Dichlorophthalonitrile

作　　者：吴永富[1] 孙纲春[1] 李俊海[1] 王树钊[1] 

机构地区：[1]河南工业大学化学化工学院,河南郑州450001

出　　处：《化学与生物工程》2008年第10期16-17,20,共3页Chemistry & Bioengineering

基　　金：河南工业大学引进人才资助项目(150207)

摘　　要：以4,5-二氯邻苯二甲酸为原料,经过乙酸酐脱水、甲酰胺亚胺化、氨水氨解、三氯氧磷脱水合成了4,5-二氯邻苯二甲腈。对反应步骤进行了简化,发现亚胺化后用一锅加的方法直接进行氨解合成4,5-二氯邻苯二甲酰胺,可提高产率。With 4, 5-dichlorophthalic acid as raw material, 4, 5-dichlorophthalonitrile was synthesized through dehydration by acetic anhydride,imidization by formamide,ammonolysis by ammonia solution and dehydration by phosphorus oxychloride. It was found that 4,5-dichlorophthalamide could be directly synthesized with one-pot method, which not only simplified the operation, but also improved the reaction yield.

关 键 词：邻苯二甲腈 4 5-二氯邻苯二甲腈 合成 

分 类 号：O625.67[理学—有机化学]