急性脑梗死抑郁症的相关因素分析及防治研究  

Analysis of the correlative factors of melanchaolia after acute cerebral infarction and its prevention and cure studies with paroxil

作　　者：林香玉[1] 王丽华[1] 栾秀香[1] 郑娟[1] 张惠娟[1] 

机构地区：[1]山东省烟台市烟台山医院,264001

出　　处：《中国现代药物应用》2008年第21期12-14,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨急性脑梗死抑郁症发生相关因素以及预防治疗。方法选择急性脑梗死患者153例,入院后常规做CT或MRI检查,记录病灶的部位、大小以及数量,第10天使用汉密尔顿抑郁量表(HAMD)进行抑郁评估,以加拿大神经功能缺失量表进行神经功能缺失评分。分析抑郁症的发生与病变部位,病灶的大小,神经功能缺失程度的关系,并同时采用心理干预与5-羟色胺再摄取抑制剂(SSRIs)帕罗西汀进行治疗。结果153例患者抑郁症的发生率为37.9%,并且与病灶的部位,大小有关系,与性别、神经功能缺失评分呈正相关。治疗后HAMD、CNS评分明显改善。结论急性脑梗死抑郁症的的发生率与性别、神经功能缺陷评分(CNS)呈显著正相关,与病灶的部位,大小对抑郁的发生有预示作用。Objective To explore the correlative factors on melanchaolia after acute cerebral infarction and its prevention and cure studies. Methods 153 patients with acute cerebral infarction were examined by CT immediately after hospitalization. Position, size and the number of the infarcion sites were recorded, and on the 10th day all were assessed respectively by Hamilton depression scale（HAMD） and by Canadian Neurologie- deficiency Scale（CNS）. The correlation of melanchaolia and the sites , size of cerebral infarction and neuralde- fieieney scale were analyzed. Psycological intervention and cure with paroxil were used on melanchaolia patients. Results The morbidity of melanehaolia was 37.9% in 153 patients, which was related with position and size of infarction and had a positive correlation with sex and scores on CNS results. The HAMD and CNS results were greatly increased after treatment. Conclusions Melanchaolia incidence in the acute cerebral infarction and convalescence period of cerebral haemorrhagia has positive correlationship with sex , CNS.

关 键 词：急性脑梗死 抑郁症 梗死部位 梗死灶大小 防治方法 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]