乳腺癌中突变型p53与COX-2蛋白的相关性研究  

Correlation of mutant p53 and COX-2 protein in breast carcinoma

作　　者：傅春玲[1] 张世琼[1] 吴文长[1] 罗敏[1] 

机构地区：[1]涪陵中心医院病理科,重庆涪陵408000

出　　处：《现代医药卫生》2008年第22期3344-3345,共2页Journal of Modern Medicine & Health

摘　　要：目的:探讨突变型p53和环氧化酶-2(cyclooxygenase-2,COX-2)蛋白在乳腺癌组织中表达的相关性及其对预后的影响。方法:采用S-P免疫组织化学技术检测60例乳腺癌组织中突变型p53和COX-2蛋白的表达。结果:60例乳腺癌组织中p53蛋白阳性32例(53.3%),COX-2蛋白阳性47例(78.3%);p53蛋白的表达与组织学分级显著相关(P<0.05),COX-2蛋白的表达与淋巴结转移和肿瘤大小显著相关(P<0.05);p53蛋白阳性组COX-2蛋白阳性表达率高于p53蛋白阴性组(P<0.05)。结论:突变型p53和COX-2蛋白的表达有关,COX-2可作为判断乳腺癌患者预后的潜在指标。Objective：To investigate the association of mutant p53 and COX-2 protein in breast carcinomas and its influence on prognosis. Methods：The expressions of mutant p53 and COX-2 protein were detected in breast carcinomas （60 cases） by immunoshistochemisty （SP method）. Results：The positive rates of mutated p53 and COX-2 protein were 53.3%（32 cases） and 78.3%（47 eases） in breast carcinomas respectively.The expression of p53 was related to histopathological grading（P〈0.05）.The expression of COX-2 was related to lymphatic metastasis and tumor size （P〈0.05）. The COX-2 expression in group of mutant p53 as positive was higher than that in mutant p53 as negative. Conclusion：Mutant p53 protein can improve the expression of COX-2,which may serve as a potential marker of prognosis in breast carcinomas.

关 键 词：乳腺肿瘤 P53 环氧化酶-2 预后 

分 类 号：R36[医药卫生—病理学]