阿立哌唑治疗利培酮所致男性高催乳素血症研究  

Clinical study of aripiprzole in treatment of hyperprolactinemia caused by risperidone

作　　者：宋梓祥[1] 徐乐平[1] 蔡占魁[1] 汪卫华[1] 汪广剑[1] 王焕林[1] 

机构地区：[1]江苏常州市解放军第102医院,全军精神卫生中心213003

出　　处：《临床精神医学杂志》2008年第5期337-338,共2页Journal of Clinical Psychiatry

摘　　要：目的:探讨阿立哌唑治疗利培酮所致男性高催乳素血症的疗效。方法:将60例利培酮所致高催乳素血症的男性精神分裂症患者随机分为两组,分别用阿立哌唑(30例)及安慰剂(30例)治疗,疗程6周。分别于治疗前、治疗6周检测血清催乳素(PRL)水平,评定简明精神病评定量表(BPRS)及治疗中出现的症状量表(TESS)。结果:治疗6周末,阿立哌唑组PRL较治疗前显著下降(P<0.001),男性乳房女性化消失(11/13),自发泌乳消失(18/19);安慰剂组PRL治疗前后差异无显著性(P>0.05)。结论:阿立哌唑可有效治疗利培酮所致的男性高催乳素血症。Objective： To explore the efficacy and tolerability of aripiprazole in the treatment of hyperprolactinemia caused by risperidone. Method：Sixty schizophrenic patients with hyperprolactinemia associated with risperidone were randomly divided into aripiprazole group（ n = 30）and placebo group（ n = 30）,receiving 6 weeks treatment . The prelactin （PRL） was measured at the baseline and the end of study. The efficacy and side effects were assessed with the brief psychiatric rating scale （BPRS） and the treatment emergent symptom scale （TESS） before and after treatment. Results ： The concentration of PRL decreased significantly in aripiprazole group after treatment （P 〈 0. 001 ）. Disappearance of feminine-like breast presented in male patients （ 11/13 ） and spontaneous lactation（ 18/19）were observed in aripiprazole group. There were no significant differences before and after treatment in placebo group （ P 〉 0.05 ）. Conclusion ： Aripiprazole is effective in the treatment of hyperprolactinemia caused by risperidone.

关 键 词：阿立哌唑 利培酮 高催乳素血症 精神分裂症 

分 类 号：R749.053[医药卫生—神经病学与精神病学]