强直性脊椎炎与HLA-B27等位基因研究  

STUDY ON ANKYLOSING SPONDYLITIS AND HLAB27 ALLELES

作　　者：蒋黎华[1] 范丽安[1] 杨珏琴[1] 姚芳娟[1] 周嘉陵[1] 许荣 高培娣 

机构地区：[1]上海第二医科大学上海市免疫学研究所

出　　处：《中国免疫学杂志》1997年第6期345-348,共4页Chinese Journal of Immunology

基　　金：国家自然科学基金;卫生部科学基金

摘　　要：为探索强直性脊椎炎与ＨＬＡ－Ｂ２７关联机理，建立非同位素地高辛标记的ＰＣＲ／ＳＳＯ方法对中国上海地区６８例ＨＬＡ－Ｂ２７阳性的强直性脊椎炎病人和７例ＨＬＡ－Ｂ２７阳性正常对照进行了ＨＬＡ－Ｂ２７等位基因的检测，结果显示在病人和正常对照组中Ｂ＊２７０４都是最常见的等位基因，各占７６．８％和７１．４％，Ｂ＊２７０５亦是常见的等位基因，分别占２０．３％和２８．６％，两组间比较差异无显著性；在病人组还检出Ｂ＊２７０６和Ｂ＊２７０７各１例，提示此两等位基因可能也与ＡＳ关联。此结果为研究强直性脊椎炎与ＨＬＡ－Ｂ２７关联的机制提供了有用的资料。To explore the mechanism of association between ankylosing spondylitis and HLAB27,had investigated the distribution of HLAB27 alleles in 68 cases of B27 positive AS patients and 7 cases of B27 positive healthy controls using nonradioactive digoxigenin labelled PCR/SSO method.The result showed that B*2704 is the most common allele in both patient and control groups(76.8% and 71.4% respectively).B*2705 is also a common allele with allele frequences 20.3% and 28.6% seperately.Neither of the two alleles is significantly different between patients and controls.Interestingly,had detected case of one B*2706 allele and one B*2707 allele in patient group,which suggested these two alleles may be associated with AS.

关 键 词：强直性脊椎炎 HLA-B27 等位基因 

分 类 号：R593.230.3[医药卫生—内科学]