MTA1及nm23H1基因在新疆哈萨克族食管癌组织中的表达及临床意义  

Expression and signifiance of nm23H1 and MTA1 gene in Kazak's esophageal cancer

作　　者：李海燕[1] 李惠武[2] 陈艳[1] 李卉[2] 卢晓梅[3] 庞作良[4] 王洪江[4] 赵学信[1] 

机构地区：[1]新疆医科大学基础医学院生物化学暨分子生物学教研室 [2]新疆医科大学基础医学院科研中心,新疆乌鲁木齐830000 [3]新疆医科大学第一附属医院医学研究中心,新疆乌鲁木齐830000 [4]新疆医科大学附属肿瘤医院胸外科,新疆乌鲁木齐830000

出　　处：《新疆医科大学学报》2008年第8期943-945,共3页Journal of Xinjiang Medical University

基　　金：新疆维吾尔自治区高技术研究与发展计划项目(200810103)

摘　　要：目的:研究肿瘤转移相关基因(MTA1)及nm23H1基因在哈萨克族食管癌组织中的表达及临床意义。方法:应用逆转录多聚酶链反应(RT-PCR)技术检测MTA1及nm23H1基因在20例食管癌组织及其相应癌旁组织中的表达。结果:癌组织中nm23H1阳性表达占50.00%(10/20),有淋巴结转移的癌组织中nm23H1mRNA的阳性表达率为40.00%(4/10),无淋巴结转移的为60.00%(6/10);浸润至外膜层的肿瘤中阳性表达率为71.43%(10/14)。MTA1基因在癌组织中有5例(25.00%)表达,且均为T3期肿瘤,癌旁组织仅1例表达。结论:nm23H1及MTA1基因的表达可能与哈萨克族食管癌的发生及浸润深度有关,二者协同作用,共同促进食管癌的发生及发展。Objective： To study the expression and signifiance of nm23H1 and MTA1 gene in carcinogenesis and metastasis of Kazak＇s esophageal cancer. Methods： The expression of nm23H1 and MTA1 genes were detected in 20 cases of esophageal cancer tissues and tumor-adjacent normal tissues by the methods of reverse transcription polymerase chain reaction, and the signifinance with clinical pathology were analysised. Results： Compared with 20 cases esophageal cancer and tumor adjacent normal tissues, the high expression rate of nm23H1 in esophageal cancer tissues was 50%（10/20）. The frequency of nm23H1 overexpression was 40% with lymphoid node metastasis, 60% in those without metastasis and 71.43% in T3 stage carei noma. The high expression rate of MTAI gene in esophageal cancer tissues was 25% （5/20）, and all in T3 stage carcinoma. Conclusions： Nm23H1 gene and MTA1 gene have important role in carcinogenesis and development of Kazak＇s esophageal cancer. The joint action of Nm23H1 gene and MTA1 gene can promote carcinogenesis and development of Kazak＇s esophageal cancer.

关 键 词：肿瘤转移相关基因 NM23H1基因 哈萨克族食管癌 转移 

分 类 号：R737.31[医药卫生—肿瘤] R73-31[医药卫生—临床医学]