罗勒水提物对内皮细胞损伤大鼠模型的保护作用  

The protective effect of aqueous extract of ocimum basilicum L. on endothelial cell injury

作　　者：蒋进[1] 依巴代提.托乎提 艾尼瓦尔.吾买尔[1] 

机构地区：[1]新疆医科大学药学院药理学教研室

出　　处：《新疆医科大学学报》2008年第9期1148-1150,共3页Journal of Xinjiang Medical University

摘　　要：目的:探讨罗勒水提物对肾上腺素(Adr)致血管内皮细胞损伤(VEC)的保护作用。方法:皮下注射Adr建立血管内皮细胞损伤大鼠模型,胸主动脉切片检查VEC损伤大鼠血管内皮受损情况,采用酶联免疫吸附测试法(ELISA)测定VEC损伤大鼠血浆血管性假血友病因子和组织型纤溶酶原激活物含量。结果:罗勒水提物能显著减轻VEC损伤大鼠动脉内皮层的损伤程度,明显降低血浆血管性假血友病因子水平,显著升高血浆组织型纤溶酶原激活物水平,与模型组相比有统计学差异。结论:罗勒水提取物对受损血管内皮细胞具有良好的保护作用。Objective：To study the protective effect of aqueous extract of ocimum basilicum on endothelial cell injury inducing by adrenaline.Methods：Models of endothelial injury was established via pro injecting adrenaline.The damaged degree of vascular endothelial cell was evaluated by aorta pectoralis pathologic slice.The content of vWF and t-PA in rat plasma was measured by ELISA.Results：Compared to those of the model group,aqueous extract of ocimum basilicum can significantly lessen the degree of artery endothelial cell injury,significantly decrease the content of vWF in endothelial injury rat plasma and increase the content of t-PA.Conclusion：Aqueous extract of ocimum basilicum presented the protective effect on vascular endothelial cell.The possible mechanisms for this effect may be due to improved the excrete function of vascular endothelial cell.

关 键 词：罗勒水提物 内皮细胞 血管性血友病因子(vWF) 肾上腺素 

分 类 号：R-332[医药卫生] R914