左卡尼汀对尿毒症血液透析病人营养状况的改善作用  

The improvement of Nutrition Indexes of L-carnitine in maintenance hemodialysis patients

作　　者：高继玲[1] 王长玲[1] 张淑萍[1] 刘晓红[1] 刘黎明[1] 

机构地区：[1]新疆医科大学附属中医医院肾病科,新疆乌鲁木齐830000

出　　处：《新疆医科大学学报》2008年第9期1195-1197,共3页Journal of Xinjiang Medical University

摘　　要：目的:研究静脉注射左旋卡尼汀对维持血液透析(HD)患者肉碱缺乏症的治疗作用。方法:采用随机、对照的研究方法,选择HD患者54例,分为治疗组、对照组,每次透析结束后,治疗组静脉注射左旋卡尼汀1g,对照组注射生理盐水,为期3个月。结果:治疗组体力、精神状态、食欲、恶心、呕吐、透析耐受性、透析中肌痉挛或低血压等症状改善(P<0.01),治疗组与对照组相比变化差异有统计学意义(P<0.01);治疗组血浆总蛋白、白蛋白和转铁蛋白等营养参数也明显升高。结论:左旋卡尼汀能安全有效地治疗维持HD患者肉碱缺乏症。Objective：To investigate the effect of intravenous infusion of L-carnitine at the end of each dialysis treatment for 3 months.Methods：The trial was placebo controlled and randomized.54 hemodialysis patients were divided into two groups：treatment group（n=30）and control（n=24）group.In treatment group,1 g of L-carnitine was infused to the patients at the end of each dialysis treatment for 3 months,while normal saline was given to the control group.Clinical and laboratory parameters were studied.Results：Physical and mental status,nausea and vomiting,dialysis tolerance,intradialytic hypotension and cramps were improved significantly in the treatmemt.Serum albumin and transferrin were also elevated in the treated groups.Conclusion：Intravenous supplement of L-carnitine in hemodialysis patients appear to be associated with an improvement of clinical status,decrease of inra-dialytic symptoms,sense of well being and certain serum nutritional indexes.

关 键 词：血液透析 肉碱 左卡尼汀 

分 类 号：R973[医药卫生—药品] R692.5[医药卫生—药学]