hTERT的转录调节的研究进展  

Studying progress of hTERT transcriptional regulation

作　　者：张险峰[1] 江应安[1] 罗和生[1] 陈维进[2] 

机构地区：[1]武汉大学人民医院消化内科,430060 [2]湖北省黄石市中心医院,435000

出　　处：《国际消化病杂志》2008年第5期427-429,共3页International Journal of Digestive Diseases

基　　金：国家自然科学基金资助项目(30471690)

摘　　要：人肿瘤细胞的显著特征是永生化生长,永生化生长与端粒酶保持端粒长度有关。正常细胞与肿瘤细胞hTERT(human telomerase reverse transcriptase)的转录调节主要机制分别通过端粒酶活性的负、正反馈调节。hTERT启动子通过细胞和病毒的因素及途径参与细胞衰老、永生化及癌变。hTERT启动子活性受致癌基因、抑癌蛋白的直接调节或通过信号转导调节。病毒基因整合在hTERT位点可导致hTERT激活、诱导端粒酶产生。Human cancer cells is immortal cell, which is associated with telomere maimenance by telomerase. The transcriptional regulation of the human telomerase reverse transcriptase （hTERT） gene is a major mechanism that negatively and positively controls telomerase activity in normal and cancer cells, respectively. The cellular and viral factors and pathways involved in cell senescence, immortalization and carcinogenesis act on the hTERT promoter. The activity of the hTERT promoter is regulated, either directly or through signaling pathways, by oncogene products and tumor suppressor proteins. The integration of viral genomes in the hTERT locus can lead to hTERT activation and telomerase induction.

关 键 词：人端粒酶逆转录酶 永生化 端粒酶 转录调节 抑癌基因 

分 类 号：R730.2[医药卫生—肿瘤]