藏族女性青少年血清钙磷及骨代谢生化标志物水平检测结果分析  

The Levels of Serum Total Calcium,Phosphate and Biochemical Markers of Bone Turnover in Tibetan Female Adolescents

作　　者：王红梅[1] 阎鹏[1] 王平[2] 席焕久[3] 

机构地区：[1]辽宁医学院附属第一医院检验科,锦州121001 [2]潍坊医学院生化教研室 [3]辽宁医学院解剖教研室

出　　处：《中国学校卫生》2008年第10期884-886,共3页Chinese Journal of School Health

基　　金：国家自然科学基金资助项目(编号:30270696)

摘　　要：目的了解藏族女性青少年血清钙、磷及骨代谢生化标志物水平,为藏族青少年生长发育研究提供相应资料。方法采用分层整群抽样方法,从拉萨市和那曲地区中小学生中抽取12～18岁藏族健康女性青少年336名,检测血清钙(Ca)、磷(P)、碱性磷酸酶(ALP)、骨性碱性磷酸酶(BAP)、骨钙素(BGP)水平。结果藏族女性青少年血清钙与年龄不相关(P>0.05),但拉萨地区明显高于那曲地区(P<0.05)。血清P,ALP,BAP,BGP水平与年龄均呈负相关(P值均<0.01),且各指标在多数年龄组表现为拉萨地区明显高于那曲地区(P值均<0.05)。除血清钙外,其他指标之间呈显著正相关(P值均<0.01)。结论藏族女性青少年血清钙、磷及骨代谢生化标志物水平随着年龄的增加、居住地海拔高度的增加,各指标水平逐渐降低。Objective To study the change nf serum total calcium（ Ca）, phosphate（P） anti markers of bone turnover levels in Tibetan te- male adolescents, and to provide reference for the related researchs. Methods Using a stratified-muhi-steps-eluster sampling method, 336 health girls aged 12 - 18 years were selected from Lasa and Naqu to lest the levels of serum Ca, P, alkaline phnsphatase（ALP） , bone alkaline phosphatase （BAP） and hnne-gla-protein（ BGP）. Results No ton＇elation was observed between Ca and age in Tibetan female adolescents, but Ca levels of Lasa girls were higher than those of Naqu （ P 〈0.05 ）. The levels of P, ALP, BAP and BGP had a negative correlation with age（ P 〈0.01） , and positive eorrelations were observed between them（ P 〈0.05 ）. The serum P, ALP, BAP and BGP levels of Lasa were significantly higher than those of Naqu in most age groups（ P 〈0.01）. Conclusion Metaholism of calcium, phosphate and biochemical makers of bone turnover in Tibetan female adolescents maybe dedreased by the inereasing of age and the different geographical conditions.

关 键 词：钙 磷 生物学标记 血清学试验 青少年 少数民族 藏族 

分 类 号：R336[医药卫生—人体生理学] R179[医药卫生—基础医学]