半枝莲、白花蛇舌草及其药对提取物抗氧化及清除自由基活性  

Antioxidant and Free Radical Scavenging Activities of Extracts from Scutellaria barbata D.Don,Hedyotis diffusa Willd and Their Combination

作　　者：董欢欢[1] 曹树稳[1,2] 余燕影[2] 

机构地区：[1]南昌大学食品科学与技术国家重点实验室,南昌330047 [2]南昌大学化学系,南昌330031

出　　处：《天然产物研究与开发》2008年第5期782-786,802,共6页Natural Product Research and Development

基　　金：国家"十一五"科技支撑计划(2006BAI06A18-06)

摘　　要：采用几种化学及生物学模型考察了半枝莲、白花蛇舌草及其药对提取物抗氧化及清除自由基活性。研究结果表明三种提取物中,半枝莲提取物还原能力、清除DPPH及.OH自由基能力最强,药对提取物螯合Fe2+能力以及保护DNA免受自由基损伤能力最强。提示提取物抗氧化及清除自由基活性可能与其黄酮组成及含量相关。推测药对的抗癌作用机理可能与金属离子的螯合能力和对DNA损伤的保护作用等有关。The antioxidant and free radical scavenging activities of the alcohol-ethyl acetate extracts from Scutellaria barbata, Oldenlandia diffusa, and their combination were evaluated. The results showed that the reducing power, DPPH and hydroxyl radicals scavenging of Scutellaria barbata extract were much stronger than those of other tested extracts; the chelating activity of the combination extract on ferrous iron and protecting effect on DNA damage caused by hydroxyl radicals were the strongest. The antioxidant and free radical scavenging activities of the extracts may be correlated with the species and contents of flavonoid compounds. The anticancer mechanism of their combination may be associated with its chelating activity on ferrous iron and protecting effect on DNA damage caused by hydroxyl radicals.

关 键 词：半枝莲 白花蛇舌草 药对 抗氧化 清除自由基 

分 类 号：R285.5[医药卫生—中药学] Q946.91[医药卫生—中医学]