马齿苋多糖抗糖尿病作用的实验研究  

Hypoglycemia Effect of Polysaccharide from Portulaca oleracea on Alloxan-induced Diabetic Mice

作　　者：李玉萍[1] 刘志勇[2] 谢国秀[2] 苏虎[1] 周春丽[1] 王德解[1] 

机构地区：[1]江西科技师范学院生命科学学院,南昌330013 [2]江西省医学实验动物中心,南昌330006

出　　处：《天然产物研究与开发》2008年第5期813-815,865,共4页Natural Product Research and Development

基　　金：江西省教育厅科技项目(赣教技字[2007]285号)

摘　　要：为了观察马齿苋多糖的抗糖尿病作用,本实验用四氧嘧啶诱导糖尿病模型小鼠,观察了马齿苋多糖液灌胃后5、10和15d的空腹血糖浓度的改变,以及糖负荷30、60、120min后葡萄糖耐量变化。结果表明,马齿苋多糖可显著降低糖尿病模型小鼠的血糖和改善其糖耐量异常,且与处理浓度和时间呈正相关性。上述指标显示马齿苋多糖具有抗糖尿病作用。In order to study the effects of polysaccharide from Portulaca oleracea on the blood glucose level of normal and alloxan-induced diabetic mice,the polysaccharide was obtained by water extraction and alcohol precipitationfrom Portulaca oleracea and the diabetic mice models were induced by intraperitoneal injection （IP） of alloxan. After intragastric administration with crude extract and polysaccharide from Portulaca oleracea for 5,10, and 15 d, the blood glucose levels was detected by glucose sensor. Before sacrifice, blood glucose levels were determined in tail blood samples at 0,30,60, and 120 rain after glucose challenge. The polysaccharide from Portulaca oleracea can lower blood glucose levels in alloxan-induced hyperglycaemic mice, but not normal mice. A significant improvement in glucose tolerance was also observed in hyperglycaemic mice treated with polysaccharide from Portulaca oIeracea. The results showed that the polysaccharide from Portulaca oleracea has significantly hypoglycemia effect on alloxan-induced diabetic mice.

关 键 词：马齿苋 多糖 糖尿病 血糖 糖耐量 

分 类 号：R282.7[医药卫生—中药学] Q949.99[医药卫生—中医学]