人面果抗氧化活性成分研究  

Study on the Antioxidant Constituents from the Barks of Garcinia xanthochymus

作　　者：程旺元[1] 钟芳芳[1] 赵应红[2] 杨光忠[1] 陈玉[3] 

机构地区：[1]中南民族大学生命科学学院天然产物化学研究室,武昌430074 [2]云南西双版纳州民族医药研究所,西双版纳666100 [3]中南民族大学化学与材料科学学院,武昌430074

出　　处：《天然产物研究与开发》2008年第5期836-838,895,共4页Natural Product Research and Development

基　　金：国家自然科学基金(30670215)

摘　　要：采用DPPH法对人面果树皮和根部不同溶剂提取物进行抗氧化活性研究。结果表明人面果树皮乙酸乙酯提取物的抗氧化活性最强。运用正相和反相硅胶柱层析对人面果树皮乙酸乙酯提取物进行分离纯化,用波谱技术(1D和2D NMR)分析鉴定出2个xanthone类化合物:1,5-dihydroxy-3-methoxyxanthone(1)和2,5-di-hydroxy-1-methoxyxanthone(2),化合物1和2均为首次从该植物中发现。对化合物1和2进行抗氧化活性研究,结果表明化合物1和2显示了一定的抗氧化活性。The antioxidant activities of each extract from Garcinia xanthochymus was determined by using DPPH free radical scavenging method. The experimental results indicated that EtOAc extract of the bark had the strongest antioxidation activities. Then two compounds,1,5-dihydroxy-3-methoxyxanthone（1） and 2,5-dihydroxy-1-raethoxyxanthone（2） were isolated by normal-phase and reverse-phase silical gel column chromatography from the this extract. Their structures were identified by spectral data（ 1D and 2D NMR）. These compounds were obtained from this plant for the first time. The antioxidant activities of two compounds were tested. The results showed that the two compounds displayed moderate antioxi- dant activities compared with BHT.

关 键 词：藤黄属 咕吨酮 抗氧化活性 

分 类 号：R284.2[医药卫生—中药学] Q946.3[医药卫生—中医学]