纤维母细胞活化蛋白（FAP—alpha）研究的临床意义  

Clinical implication of fibroblast activation protein α （FAPα）

作　　者：CHEN Ling 王喜梅[2] 张众[3] 

机构地区：[1]Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655 [2]湖南省怀化医学高等专科学校基础医学部,湖南怀化418000 [3]大连医科大学,辽宁大连116027

出　　处：《世界肿瘤杂志》2008年第3期191-194,共4页Tumour Journal of the World

摘　　要：肿瘤间质纤维母细胞，不同于静息状态成人正常组织的纤维母细胞，特征性地表达一种糖蛋白-纤维母细胞活化蛋白（FAPα），FAPα具有二肽酰肽酶及胶原酶蛋白水解活性，因而可以降解二肽，也可以降解凝胶及Ⅰ型胶原，间质降解是肿瘤细胞侵袭的基本条件之一。以FAPα作为肿瘤生物标记以诊断及治疗肿瘤正在成为一个新兴领域。The stromal fibroblasts of cancer, functionally distinct from the resting fibroblasts in normal adult tissue, characteristically form a specific membrane protein known as fibroblast activation protein α （FAPα）. This integral membrane glycoprotein is a serine protease having both dipeptidyl peptidase and collagenolytic activity capable of degrading gelatin and type I collagen. FAPα is expressed by tumor stromal fibroblasts in greater than 90% of human epithelial carcinomas and some sarcomas. Targeting FAPα on tumor stromal fibroblasts has emerged as a promising new area for cancer diagnosis and therapy.

关 键 词：FAPα SEPRASE 间质纤维母细胞 纤维母细胞活化蛋白 生物标记 

分 类 号：R730.4[医药卫生—肿瘤] R73-34[医药卫生—临床医学]