A role for uninjured afferents in neuropathic pain  

作　　者：Richard A. Meyer Matthias Ringkamp 

机构地区：[1]Departments of Neurosurgeory , Johns Hopkins University, Baltimore, MD 21205, USA [2]Departments of Biomedical Engineering and the , Johns Hopkins University, Baltimore, MD 21205, USA [3]Departments of Applied Physics Laboratory, Johns Hopkins University, Baltimore, MD 21205, USA

出　　处：《生理学报》2008年第5期605-609,共5页Acta Physiologica Sinica

基　　金：grants from the National Institutes of Health(NS-41269,NS-14447)

摘　　要：Diseases and injuries to the nervous system can lead to a devastating chronic pain condition called neuropathic pain.We review changes that occur in the peripheral nervous system that may play a role in this disease.Common animal models for neuropathic pain involve an injury to one or more peripheral nerves.Following such an injury,the nerve fibers that have been injured exhibit many abnormal properties including the development of spontaneous neural activity as well as a change in the expression of certain genes in their cell body.Recent data indicate that adjacent,uninjured nerve fibers also exhibit significant changes.These changes are thought to be driven by injury-induced alterations in the milieu surrounding the uninjured nerve and nerve terminals.Thus,alteration in neural signaling in both injured and uninjured neurons play a role in the development of neuropathic pain after peripheral nerve injury.Diseases and injuries to the nervous system can lead to a devastating chronic pain condition called neuropathic pain. We review changes that occur in the peripheral nervous system that may play a role in this disease. Common animal models for neuropathic pain involve an injury to one or more peripheral nerves. Following such an injury, the nerve fibers that have been injured exhibit many abnormal properties including the development of spontaneous neural activity as well as a change in the expression of certain genes in their cell body. Recent data indicate that adjacent, uninjured nerve fibers also exhibit significant changes. These changes are thought to be driven by injury-induced alterations in the milieu surrounding the uninjured nerve and nerve terminals. Thus, alteration in neural signaling in both injured and uninjured neurons play a role in the development of neuropathic pain after peripheral nerve injury.

关 键 词：神经性疼痛 病症 临床分析 感觉神经元 

分 类 号：R741[医药卫生—神经病学与精神病学]