术中输注万汶对乳腺癌根治术患者围术期血浆细胞因子的影响  

EFFECTS OF INFUSION WITH 6% HES130/0.4 ON LEVELS OF PERIOPERATIVE PLASMA CYTOKINES IN BREAST CANCER PATIENTS UNDERGOING RADICAL CORRECTION

作　　者：甘建辉[1] 郭东勇[2] 高鲁渤[2] 邓乃封[3] 

机构地区：[1]华北煤炭医学院附属人民医院麻醉科,唐山063000 [2]天津医科大学附属肿瘤医院麻醉科 [3]天津医科大学第二附属医院麻醉科

出　　处：《现代预防医学》2008年第21期4293-4294,4297,共3页Modern Preventive Medicine

摘　　要：[目的]观察万汶（6％羟乙基淀粉130／0．4）对乳腺癌根治术患者围术期血浆细胞因子的影响。[方法]选择ASAⅠ～Ⅱ级择期行乳腺癌手术患者30例，随机分为乳酸钠林格液（L组，n=10）、贺斯（6％羟乙基淀粉200／0．5）组（H组，n=10）和万汶组（W组，n=10）。分别于麻醉诱导前（T1）、术毕时（T2）、术后24h（B）和术后72h（T4）分别采取外周静脉血，用酶联免疫吸附法（ELISA）检测血浆IL-2、IL—6、IL-8和IL-10水平。[结果]W组和H组患者子手术结束时、手术后24h和72h血浆IL-2、IL-6、IL-8和IL—10水平明显高于麻醉前（P〈0．05），L组手术结束时和手术后24h血浆IL-2和IL-10水平明显低于麻醉前（P〈0．05）除外，其余均和W组和H组变化相似；且两组与L组比较差异有统计学意义（P〈0．05），但W组和H组间相应时点比较差异无统计学意义（P〉0．05）。[结论]万汶和贺斯均能预防或减轻手术和麻醉导致的免疫抑制，且两者比较无明显差异。因此万汶和贺斯均可安全用于肿瘤病人。[Objective] To observe the effects of 6%HES130/0.4 on cytokines of the breast cancer patients underwent radical correction. [ Methods] Thirty breast cancer patients underwent radical correction were randomly divided into three groups： Group L received Ringer＇s solution. Group H received 6%HES200/0.5 and Group W received 6%HES130/0.4. Blood samples from radial vein were taken before anesthesia, end of operation and 24h and 72h after operation, to determine and compare between the groups at the time point of the levels of IL-2, IL-6. IL-8 and IL-10. [Results] Compared with T1, IL- 2, IL-6, IL-8 and IL-10： the levels of T2 T3 and T4 were significant differences in three group （P〈 0.05）, but the levels of T4 returned to the levels of T1; IL-12 and IFN-γ the levels of T4 increased significantly in group E and P （P 〈 0.05）. At the same time point, the level of all cytokines were of no significant differencely different between group W and group H （P 〉 0.05） and were significant different between group L and other two groups （P 〈 0.05）. [Conclusion] Infusion with 6%HES130/0.4 and 6%HES200/0.5 can prevent or reduce the immunological depression in breast cancer patients undergoing radical correction, and two groups are not significantly different. So 6%HES130/0.4 and 6%HES200/0.5 can be safely applied in the cancer patients.

关 键 词：万汶 贺斯 乳腺癌 细胞因子 

分 类 号：R737.9[医药卫生—肿瘤]