免疫组化检测14-3-3ζ在临床肺癌中的表达  

Expression of 14-3-3ζ protein in clinical lung carcinoma

作　　者：陈惠华[1] 孟宇宏[2] 徐元基[1] 杜芝燕[1] 王妍[1] 谭晓刚[1] 陆应麟[1] 

机构地区：[1]军事医学科学院基础医学研究所,北京100850 [2]海军总医院病理科,北京100037

出　　处：《军事医学科学院院刊》2008年第5期455-457,共3页Bulletin of the Academy of Military Medical Sciences

基　　金：国家自然科学基金资助(30271452,30471947);国家“973”计划资助项目(2002CB513105)

摘　　要：目的:探讨14-3-3ζ与肺癌转移的关系。方法:以免疫组织化学染色检测14-3-3ζ在临床肺癌标本原发灶与转移灶的表达情况,探讨14-3-3ζ与肿瘤转移的相关性。结果:在所有的肿瘤标本中均检测到14-3-3ζ的表达,其中15例标本原发灶14-3-3ζ的表达水平高于转移灶。结论:14-3-3ζ与肺癌转移具有一定的相关性。Objective：To investigate the relationship between 14-3-3ζ and lung cancer metastasis. Methods： Immuno- histochemical staining was employed to examine 14-3-3ζ expression. Primary and metastatic carcinoma specimens from 20 lung cancer patients were tested. Results： 14-3-3ζ expression was detected in all specimens and in 15 patients, 14-3-3ζ was expressed more highly in primary than in metastatic carcinoma. Conclusion： 14-3-3ζ has some correlation with metastasis of lung cancer.

关 键 词：14—3—3ζ 肿瘤转移 肺肿瘤 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]