KISS-1和MMP7在非小细胞肺癌组织中的表达及意义  

Expression of KISS-1 and MMP7 in human non-small cell carcinoma and its significances

作　　者：邢亚恒[1] 张庆宪[1] 李春燕[1] 

机构地区：[1]郑州大学第一附属医院,河南郑州450052

出　　处：《山东医药》2008年第29期32-33,共2页Shandong Medical Journal

摘　　要：目的探讨肿瘤抑制基因KISS-1和基质金属蛋白酶7(MMP7)在非小细胞肺癌(NSCLC)发生、发展中的作用。方法采用免疫组织化学SABC法检测58份NSCLC组织(NSCLC组)和23份正常肺组织(对照组)中KISS-1与MMP7蛋白的表达水平。结果与对照组比较,NSCLC组KISS-1阳性率明显降低(P<0.05),MMP7阳性率明显升高(P<0.05);三者表达水平与淋巴结转移、临床分期密切相关,与分化程度、组织类型、吸烟、年龄、性别无明显相关性。结论KISS-1和MMP7在NSCLC中的异常表达与肿瘤的生长和转移有关;有助于判断患者的预后。Objective To investigate the role of KISS-1 and MMP7 in the genesis and development of NSCLC. Methods The expression of KISS-1 and MMP7 was detected in 58 NSCLC tissues and 23 normal lung tissues as control by immunohiatochemical method SABC. Results The expression positive rate of KISS-1 protein in the tissue of NSCLC was significantly lower than that of the control （ P 〈 0.05 ）, the positive rate of MMP7 protein was significantly higher than that of the control （P 〈 0.05 ）. The expression level of KISS-1 and MMP7 protein were closely related to lymph node metastasis, clinical stages （ P 〈 0.05 ）, but not to differentiations, histological classification, smoke, age, and sex （ P 〉 0.05）. Condusion Abnormal expression of KISS-1 and MMP7 may play an important role in the growth and metastasis in human NSCLC. Detection of KISS-1 and MMP7 expression may be helpful to predict the prognosis of patients with NSCLC.

关 键 词：肺肿瘤 非小细胞肺癌 免疫组织化学 KISS-1 基质金属蛋白酶 

分 类 号：R361[医药卫生—病理学] R734.2[医药卫生—基础医学]