载脂蛋白E基因多态性与相关疾病关系的研究进展  

Research Progress of Relationship between Apolipoprotein E Gene Polymorphisms and Related Disease

作　　者：聂荔[1] 许虹[1] 

机构地区：[1]昆明医学院第一附属医院神经内科,昆明650032

出　　处：《医学综述》2008年第21期3233-3236,共4页Medical Recapitulate

摘　　要：载脂蛋白E(ApoE)是血浆主要载脂蛋白之一,主要由肝脏合成和代谢,它具有多种生物学活性,不仅与血脂代谢和动脉粥样硬化密切相关,而且还参与神经细胞的修复和免疫调节,与正常老化、病理老化中的认知功能缺损相关联,对人类智能有一定的影响。近年来的研究发现,ApoE不同基因型对脂质代谢、动脉硬化及冠状动脉粥样硬化性心脏病有影响,同时与中枢神经系统疾病如脑梗死、阿尔茨海默病、多发性硬化等,以及精神分裂症有关。本文就此方面的研究进行简要综述,阐述了ApoE基因的作用,对这些疾病的防治有重要意义。Apolipoprotein E （ApoE）, which is the one of the major apolipoprotein in plasma, is mairdy synthesized and metabolized by liver, not only has the various biological active, but also closely related to lipometabolism and arterial sclerosis,involving in repairment and immune regulations of nerve cell, related to impairment of cognitive functions of normal and pathological senilism, affecting to human intelligence. Recent research showed, different genotype of ApoE has various affect to lipometabolism, forming of arterial sclerosis and cardiovascular disease, meanwhile ApoE is also related to disease of center nervous system such as cerebral infarction, Alzheimer disease, multiple sclerosis and schizophrenia. This paper reviews the recent progress in the study of ApoE.

关 键 词：载脂蛋白E 脑血管病 阿尔茨海默病 多发性硬化 基因 

分 类 号：R744.51[医药卫生—神经病学与精神病学]