帕金森病环境毒素模型的研究进展  

Progress in Environmental Toxins Model of Parkinson′s Disease

作　　者：张闿艺[1,2] 黄小军[3] 黄晓峰[2] 

机构地区：[1]第四军医大学口腔医学系二队,西安710032 [2]第四军医大学基础部中心实验室,西安710032 [3]第四军医大学基础部教学实验中心,西安710032

出　　处：《医学综述》2008年第21期3272-3275,共4页Medical Recapitulate

摘　　要：帕金森病(PD)是中老年人最常见的中枢神经系统退行性疾病之一,其发病率仅次于阿尔茨海默病,但发病机制至今尚不明确。目前认为PD是多种因素共同作用的结果,环境因素与PD的关系非常密切,MPTP-PD是造成PD的重要因素之一,除MPTP外,多种环境毒素参与PD的发生,如百草枯、代森锰和鱼藤酮等,其中有的作为农药被广泛应用,因此研究环境毒素与PD的关系无疑成为意义重大的课题之一。Parkinson＇s disease （ PD ） , a kind of regressive disease of central nervous system （ CNS ） , has been common in wrinkly and elderly people. The prevalence of this disease was next to Alzheimer disease,but its pathogenesis is still unclear. At present,Parkinsonism was regarded to be caused by combination of many factors. Exposure to environmental toxins such as MPTP, paraquat, maneb, and rotenone has been demonstrated to be associated with Parkinsonism. These environmental toxins are widely used in agricultural regions. It should have great prospects in the pathogenesis of PD to explore the relevance of PD and environmetal toxins.

关 键 词：帕金森病 环境毒素 1-甲基4-苯基-1 2 3 6-四氢吡啶 百草枯 代森锰 鱼藤酮 

分 类 号：R742.5[医药卫生—神经病学与精神病学]