葡萄糖神经酰胺合成酶在肿瘤多药耐药中的研究  

Glucosylceramide synthase in tumor multidrug-resistance

作　　者：殷莉(综述)[1] 陈宝安(审校)[1] 

机构地区：[1]东南大学临床医学院附属中大医院血液科,南京210009

出　　处：《国际肿瘤学杂志》2008年第10期732-735,共4页Journal of International Oncology

基　　金：国家自然科学基金资助项目（30740062）

摘　　要：葡萄糖神经酰胺合成酶（GCS）参与神经酰胺（Cer）糖基化代谢途径，能阻断Cer对细胞凋亡信号的转导。研究表明在多种肿瘤多药耐药细胞株中GCS含量增加且与耐药表型相关，GCS和P-糖蛋白（P-gp）在细胞耐药的生物学机制中有相关性。通过化学抑制剂以及RNA干扰技术下调GCS的水平和活性能增强肿瘤细胞对药物的敏感性。因此，抑制GCS是逆转肿瘤多药耐药的一种新机制。Glucosylceramide synthase （GCS） plays an important role in ceramide metabolism and can block apoptosis signal pathway which is mediated by ceramide. Recently, studies have demonstrated that overexpression of GCS exists in various multidrug resistant cancer cell lines and is related to drug resistant phenotype. A possible connection between GCS and P-gp is also suggested. Moreover, the level of GCS can be downregulated to increase tumor cells sensitivity by chemical inhibitor and RNA interference. Thus, inhibition of activity and expression of GCS is a new mechanism of reversing multidrug resistance.

关 键 词：葡萄糖基转移酶 抗药性 肿瘤 神经酰胺类 

分 类 号：R730.5[医药卫生—肿瘤]