吲哚马来酰亚胺类蛋白激酶C抑制剂的研究进展  

Recent Progress in Indolylmaleimide Derivatives as Protein Kinase C Inhibitors

作　　者：赵圣印[1] 邵志宇[1] 钦维民[1] 张灯青[1] 

机构地区：[1]东华大学化学化工与生物工程学院,上海201620

出　　处：《有机化学》2008年第10期1676-1684,共9页Chinese Journal of Organic Chemistry

摘　　要：吲哚马来酰亚胺类化合物是对星型孢菌素进行结构改造而得到的一类新型蛋白激酶C抑制剂.对近年来吲哚马来酰亚胺类化合物在结构修饰、合成和生物活性等方面的研究进行了总结和概述,重点介绍了吲哚马来酰亚胺类化合物的合成方法,讨论了各种合成方法的优缺点.Indolylmaleimides, derived from staurosporine, is a specific class of protein kinase C inhibitors. The structure modification, synthesis and biological activity of indolylmaleimide derivatives have been reviewed in this paper. The main parts are focused on the introduction of the synthetic routes. Both merits and limitations of the synthetic methods have been discussed.

关 键 词：吲哚马来酰亚胺 蛋白激酶C抑制剂 结构修饰 合成 生物活性 

分 类 号：R98[医药卫生—药品]