“云克”与^(153)Sm-EDTMP改良法联合治疗肿瘤骨转移癌的疗效分析  

Comparison of Yunke and ^(153)Sm-EDTMP in modified combined treatment of patients with skeletal metastases

作　　者：程光华[1] 吴克芳[1] 戴云海[2] 杨军[1] 苏晓丽[3] 

机构地区：[1]皖南医学院附属弋矶山医院核医学科,安徽芜湖241001 [2]上海交通大学医学院附属仁济医院核医学科,上海200001 [3]上海中医药大学附属龙华医院,上海200032

出　　处：《皖南医学院学报》2008年第5期332-333,共2页Journal of Wannan Medical College

基　　金：安徽省教育厅科研计划项目(2002JK318)

摘　　要：目的:分析"云克"与153Sm-EDTMP两种联合方法治疗对肿瘤骨转移癌疗效的优劣。方法:51例骨转移癌患者,其中27例患者采用经典法治疗,24例采用改良法治疗;将两组患者治疗后的"闪烁"现象发生率、骨痛缓解率和骨转移灶治疗有效率进行对比分析。结果:经典法与改良法治疗后,骨痛缓解率和骨转移灶治疗有效率两组差异无显著性;而改良法治疗"闪烁"现象发生率明显低于经典法。结论:改良法治疗优于经典法,可作为临床上治疗骨转移癌最佳的联合治疗方案。Objective： To compare the curative effect of two different modalities with Yunke and ^153Sm-EDTMP in combined treatment of patients with skeletal metastases. Methods ： 27 of 51 patients with bone metastases were treated with conventional therapy（control group） while 24 were administered combined therapy with Yunke preceding ^153Sm-EDTMP（modified treatment group）. Occurrence of intensified pain, pain relief and decreased size of the metastatic lesions were compared in both groups. Results： No significant differences were found between the two groups with regard to pain relief and decreased size of metastatic lesions, but less occurrence of intensified pain was observed in modified group than the control group. Conclusion： Administration of Yunke before ^153Sm-EDTMP may decrease the frequency of pain flare in treat- ment of patients with painful skeletal metastases, and it is recommended in clinic as combined treatment in patients with skeletal metastasis.

关 键 词：“云克” ^153SM-EDTMP 骨转移 

分 类 号：R738.1[医药卫生—肿瘤]